| Bronchial hyper-reactivity in atopic patients during H2-receptor blocker treatment. | |
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MedLine Citation:
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PMID: 2425586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bronchial reactivity after Cimetidine treatment was evaluated by the histamine provocation test in 24 patients with atopic bronchial asthma and 10 patients with peptic ulcer. Anti-IgE induced histamine release from isolated basophils was also investigated. After blockade of H2 receptors, an increase of bronchial reactivity and an exacerbation of clinical symptoms were observed in 4 asthmatic patients [17%]. A moderate increase in bronchial reactivity without exacerbation of asthma symptoms was observed in 16 other patients [66%]. In some of the patients treated with Cimetidine an enhancement of IgE-induced histamine release from isolated basophils was observed. |
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Authors:
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J Hofman; Z Siergiejko; J Bortkiewicz; R Rutkowski; S Chyrek-Borowska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Agents and actions Volume: 18 ISSN: 0065-4299 ISO Abbreviation: Agents Actions Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-07-30 Completed Date: 1986-07-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213341 Medline TA: Agents Actions Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 239-41 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Asthma
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physiopathology* Bronchi / drug effects*, physiopathology Bronchial Provocation Tests Cimetidine / pharmacology Histamine / pharmacology Histamine H2 Antagonists / pharmacology* Histamine Release / drug effects Humans Peptic Ulcer / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Histamine H2 Antagonists; 51-45-6/Histamine; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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