Document Detail

Bronchial clearance of DTPA is increased in acute asthma but not in chronic asthma.
MedLine Citation:
PMID:  1731579     Owner:  NLM     Status:  MEDLINE    
To investigate bronchial permeability in asthma, we measured the bronchial clearance of 113mIn-DTPA in seven asthmatics during and after an acute attack of asthma, seven asthmatics with chronic airflow limitation, and seven asthmatics without airflow limitation but with bronchial hyperresponsiveness to methacholine. We compared these results with those from seven normal subjects, seven patients with chronic bronchitis and bronchial infection, and seven patients with emphysema. An aerosol of 113mIn-DTPA was produced with a spinning disc to ensure a predominantly bronchial deposition of inhaled particles (6.3 microns MMAD). Radioactivity over the chest was recorded with a gamma-camera for 10 min after the subject inhaled the aerosol. Central regions of interest were selected, and the logarithm of the radioactivity was plotted against time; bronchial clearance of 113mIn-DTPA was calculated as the negative slope of the regression line. Clearance was substantially higher in asthmatics during their acute attacks than in all other groups (p less than 0.0001), and it decreased toward normal levels after recovery from the acute episode. The bronchial clearance of 113mIn-DTPA in all other groups did not differ from normal. We conclude that the bronchial clearance of 113mIn-DTPA is increased in asthmatics during attacks of asthma but in the stable state is not related either to bronchial hyperresponsiveness or to airflow limitation. Our findings are best explained by an increase in permeability of the bronchial mucosa of asthmatics during acute attacks.
P Lemarchand; T Chinet; M A Collignon; G Urzua; L Barritault; G J Huchon
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  145     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-02-14     Completed Date:  1992-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  147-52     Citation Subset:  AIM; IM    
Université de Paris René Descartes, Hôpital Ambroise Paré, Boulogne, France.
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MeSH Terms
Acute Disease
Asthma / blood,  metabolism*,  physiopathology
Bronchi / metabolism*
Bronchitis / metabolism
Carbon Dioxide / blood
Chronic Disease
Forced Expiratory Volume
Indium Radioisotopes / diagnostic use
Lung Volume Measurements
Middle Aged
Oxygen / blood
Pentetic Acid / pharmacokinetics*
Pulmonary Emphysema / metabolism
Vital Capacity
Reg. No./Substance:
0/Indium Radioisotopes; 124-38-9/Carbon Dioxide; 67-43-6/Pentetic Acid; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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