Document Detail


Bronchial challenges with aerosolized food in asthmatic, food-allergic children.
MedLine Citation:
PMID:  12121190     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Allergic asthma is usually considered to be provoked by aeroallergens. However, we have recently recognized a group of children with food allergies who also develop asthma when exposed to the aerosolized form of the food. METHODS: Between 1997 and 1999 we prospectively identified children with an immunoglobulin (Ig)E-mediated food allergy who develop asthma on inhalational exposure to the relevant food allergen while it is being cooked. Subjects were exposed for 20 min to the aerosolized form of the allergen and the symptoms and the lung function were monitored. Aerosolization was achieved by cooking the food in a small room. Where possible challenges were double-blinded. RESULTS: We identified 12 children with an IgE-mediated food allergy who developed asthma on inhalational exposure to food. The implicated foods were fish, chickpea, milk, egg or buckwheat. Nine out of the 12 children consented to undergo a bronchial food challenge. Five challenges were positive with objective clinical features of asthma. Additionally, two children developed late-phase symptoms with a decrease in lung function. Positive reactions were seen with fish, chickpea and buckwheat. There were no reactions to the seven placebo challenges. CONCLUSIONS: We have presented a prospective series of children with food allergy who developed symptoms of asthma with exposure to aerosolized food allergens. Our data demonstrates that, as in the case of other aeroallergens, inhaled food allergens can produce both early- and late-phase asthmatic responses. This highlights the importance of considering foods as aeroallergens in children with coexistent food allergy and allergic asthma. For these children, dietary avoidance alone may not be sufficient and further environmental measures may be required to limit exposure to aerosolized food.
Authors:
G Roberts; N Golder; G Lack
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Allergy     Volume:  57     ISSN:  0105-4538     ISO Abbreviation:  Allergy     Publication Date:  2002 Aug 
Date Detail:
Created Date:  2002-07-17     Completed Date:  2002-09-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7804028     Medline TA:  Allergy     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  713-7     Citation Subset:  IM    
Affiliation:
Paediatric Allergy, Asthma, and Immunology, Imperial College School of Medicine at St Mary's, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Aerosols
Asthma / diagnosis*,  immunology*,  physiopathology
Bronchial Provocation Tests*
Child
Child, Preschool
Double-Blind Method
Food*
Food Hypersensitivity / diagnosis*,  immunology*,  physiopathology
Humans
Hypersensitivity, Delayed / immunology
Immunoglobulin E / immunology
Lung / physiopathology
Prospective Studies
Chemical
Reg. No./Substance:
0/Aerosols; 37341-29-0/Immunoglobulin E
Comments/Corrections
Comment In:
Allergy. 2002 Aug;57(8):659-60   [PMID:  12121181 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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