| Bronchial Inflammation, Respiratory Symptoms and Lung Function in Primary Sjögren's Syndrome. | |
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MedLine Citation:
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PMID: 21429651 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: There is no information available regarding the relationship between the respiratory symptoms or lung function and bronchial inflammation, measured by induced sputum. OBJECTIVES: Description of the clinical characteristics, radiographic images and lung function of patients suffering from Primary Sjögren Syndrome (PSS), and to assess the relationship with the inflammatory airway profile. METHODS: We analysed clinical, radiology, lung function tests, bronchial hyperresponsiveness and inflammatory data in the induced sputum from 36 consecutive patients with PSS. RESULTS: A total of 58% of patients had hoarseness and 42% had cough and dispnea. No lung dysfunction was observed, although 46% (n=16) had a positive bronchial response. Lymphocytosis >2.6% in induced sputum was observed in 69% of all sputa. There was chronic coughin 29% of patients with lymphocytosis (n=24), whereas 73% were normal (n=11) (P=.02). The duration time of cough was less for the former (P=.02). On the contrary a positive bronchial response was associated with lymphocytosis >2.6% (P=.02). Lipophages were presnt in 55% of pathological sputa (n=22) (index >15) versus 18% of the non-pathological ones (n=11) (P=.05). CONCLUSION: Hoarseness, cough and dyspnea are frequent respiratory symptoms in PSS, although there is a wide variation in the relationship with bronchial responsiveness and airway inflammation. Lymphocytosis in the airways is another site of the infiltrative process in PSS, and the induced sputum is a complementary tool in the identification of active inflammatory process. |
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Authors:
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Jesús Bellido-Casado; Vicente Plaza; César Díaz; Carme Geli; José Domínguez; Gisela Margarit; Montserrat Torrejón; Jordi Giner |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-21 |
Journal Detail:
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Title: Archivos de bronconeumologia Volume: - ISSN: 1579-2129 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0354720 Medline TA: Arch Bronconeumol Country: - |
Other Details:
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Languages: ENG; SPA Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 SEPAR. Published by Elsevier Espana. All rights reserved. |
Affiliation:
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Servicio de Neumología, Hospital de la Santa Creu i Sant Pau, Barcelona, España. |
Vernacular Title:
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Inflamación bronquial, clínica respiratoria y función pulmonar en el síndrome de Sjögren primario. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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