| [Bronchial and alveolar NO parameters in smokers]. | |
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MedLine Citation:
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PMID: 21113874 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Our aim was to determine by means of five exhaled flow rates differential parameters of FeNO and the relations between them in smokers and non-smokers. 34 smokers (without respiratory symptoms and medication) were examined. Compared to 43 healthy non-smokers, FeNO was significantly lower. The analysis of the differential NO parameters by means of the two-compartment model of NO production revealed a significant decrease in the bronchial NO concentration, but no significant changes of NO in alveolar fraction by smokers. The relations between differential parameters in non-smokers confirm the theoretical expectations of the two-compartment model. Conversely, smokers exhibit an abnormal remarkable correlation, namely, a high correlation between the reduced C(aw) und FeNO at all five flow rates. It may be assumed that the alveolar NO fraction in smokers is to some extent of bronchial origin. Such a preposition is in line with significantly decreases of FEV(1), FEF(50) and FEF(75) in smokers, which are associated with turbulences, flow inhomogeneity and a varied delay of expiration time from the peripheral airways. We hypothesize that the decreased NO concentration in the bronchial wall of smokers plays a pathophysiological role in the genesis of small airways disease. |
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Authors:
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L Barbinova; A Preisser; X Baur |
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Publication Detail:
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Type: English Abstract; Journal Article Date: 2010-11-26 |
Journal Detail:
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Title: Pneumologie (Stuttgart, Germany) Volume: 65 ISSN: 1438-8790 ISO Abbreviation: Pneumologie Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8906641 Medline TA: Pneumologie Country: Germany |
Other Details:
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Languages: ger Pagination: 103-9 Citation Subset: IM |
Copyright Information:
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© Georg Thieme Verlag KG Stuttgart · New York. |
Affiliation:
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Ordinariat und Zentralinstitut für Arbeitsmedizin und Maritime Medizin, University Medical Center Hamburg-Eppendorf. lioukov@uke.uni-hamburg.de |
Vernacular Title:
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Stickstoffmonoxid in verschiedenen Kompartimenten des Atemtrakts - Vergleich der Daten von Nichtrauchern und Rauchern. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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