Document Detail

Bromosulfophthalein disposition in chronically bile duct obstructed rats.
MedLine Citation:
PMID:  1506659     Owner:  NLM     Status:  MEDLINE    
The disposition of bromosulfophthalein was studied in chronically bile duct obstructed rats. In this model a catheter was inserted into the common bile duct and the distal tip was sealed. Resumption of bile flow was achieved with great ease. Obstruction of bile duct for 18 days in rats resulted in elevated bilirubin, ALT, AST, and alkaline phosphatase levels. Portal hypertension developed within this period (11.6 +/- 0.5 in obstructed rats vs. 8.6 +/- 0.6 mm Hg in sham-operated group). After the bile duct obstruction was opened, the half-life time for elimination of bromosulfophthalein (42.30 +/- 6.47 min) was longer than in sham-operated rats (21.23 +/- 3.34 min). Plasma clearance was reduced by 70% in bile duct obstructed rats. In spite of increased bile flow rate, biliary excretion of the dye was reduced by 40% in chronically bile duct obstructed rats. Hepatic glutathione levels were significantly reduced by 20% in this model. The specific activity of glutathione S-transferase with chlorodinitrobenzene and styrene oxide, as substrates, was reduced by 50% and 30%, respectively. However, the percent of conjugated bromosulfophthalein in bile was similar to that of sham-operated rats.
A Yaari; E Sikuler; A Keynan; Z Ben-Zvi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hepatology     Volume:  15     ISSN:  0168-8278     ISO Abbreviation:  J. Hepatol.     Publication Date:  1992 May 
Date Detail:
Created Date:  1992-09-22     Completed Date:  1992-09-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
Department of Medicine B, Soroka Medical Center, Beer Sheva, Israel.
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MeSH Terms
Alanine Transaminase / blood
Alkaline Phosphatase / blood
Aspartate Aminotransferases / blood
Bilirubin / blood
Cholestasis, Intrahepatic / blood,  complications,  metabolism*
Chronic Disease
Glutathione / analysis
Glutathione Transferase / metabolism
Hypertension, Portal / etiology,  physiopathology
Liver / chemistry,  metabolism
Rats, Inbred Strains
Sulfobromophthalein / analysis,  metabolism*
Reg. No./Substance:
297-83-6/Sulfobromophthalein; 635-65-4/Bilirubin; 70-18-8/Glutathione; EC Transferase; EC Aminotransferases; EC Transaminase; EC Phosphatase

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