| Bromocriptine requires D-1 receptor stimulation for the expression of sniffing behaviour in rats. | |
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MedLine Citation:
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PMID: 22282369 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The effect of the mixed D-1/D-2 dopamine agonist apomorphine, the D-2 agonist bromocriptine and the D- 1-selective dopamine agonist SKF 38393 on sniffing behaviour in rats was tested in the present experiments. Apomorphine induced a dose-dependent sniffing, which was decreased by either D-2 or D-1 dopamine antagonist pre-treatment. Atropine (antimuscarinic drug) or phenoxybenzamine and propranolol (α and β- adrenergic blockers, respectively) did not alter the apomorphine response. Apomorphine induced a significant increase in sniffing in reserpine-treated animals. Bromocriptine produced sniffing during the 3rd hour after drug injection. The effect was decreased by sulpiride or SCH 23390 pre-treatment. Phenoxybenzamine or propranolol did not change the bromocriptine effect, while atropine increased the drug response. SKF 38393 also induced a slight but significant sniffing. In rats pre-treated with reserpine, neither bromocriptine nor the D-1-selective agonist SKF 38393 produced any sniffing. However, the combination of bromocriptine with SKF 38393 produced an intense sniffing behaviour. It may be concluded that bromocriptine requires D-1 receptor stimulation for the expression of sniffing. |
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Authors:
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M R Zarrindast; H Naghashi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of psychopharmacology (Oxford, England) Volume: 5 ISSN: 0269-8811 ISO Abbreviation: J. Psychopharmacol. (Oxford) Publication Date: 1991 Jan |
Date Detail:
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Created Date: 2012-01-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907828 Medline TA: J Psychopharmacol Country: United States |
Other Details:
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Languages: eng Pagination: 160-5 Citation Subset: - |
Affiliation:
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Department of Pharmacology, Medical Faculty, University of Tehran, Iran. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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