Document Detail

Bromocriptine potentiation of gastric acid secretion in cats.
MedLine Citation:
PMID:  1036979     Owner:  NLM     Status:  MEDLINE    
Bromocriptine administered both orally and intravenously potentiated gastric acid secretion in response to submaximal pentagastrin stimulation in cats. Bromocriptine did not increase the maximum acid secretion in response to pentastrin, not did it stimulate basal acid secretion. Potentiation was observed in normal and vagotomized animals which precludes involvement of the vagi in the response. The mechanism of action of this compound on the stomach does not appear to be mediated through stimulation of dopaminergic receptors as no potentiation was observed with dopamine infusions. It is argued that the bromocriptine potentiation of gastric acid secretion may be a demonstration of 5-hydroxytryptamine or alpha-adrenergic antagonism. However, the potentiation observed with daily oral bromocriptine treatment had disappeared by the eighth day and may correlate with the disappearance of gastric side effects noted in patients on bromocriptine treatment.
B H Hirst; J D Reed; A Gomez-Pan; L A Labib
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical endocrinology     Volume:  5     ISSN:  0300-0664     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  1976 Nov 
Date Detail:
Created Date:  1977-03-15     Completed Date:  1977-03-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  723-9     Citation Subset:  IM    
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MeSH Terms
Bromocriptine / pharmacology*
Ergolines / pharmacology*
Gastric Juice / secretion*
Pentagastrin / pharmacology
Reg. No./Substance:
0/Ergolines; 25614-03-3/Bromocriptine; 5534-95-2/Pentagastrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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