Document Detail


Bromocriptine does not inhibit the aldosterone response to sodium depletion.
MedLine Citation:
PMID:  7042738     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was designed to investigate the influence of the dopamine agonist, bromocriptine, on the renin-angiotensin-aldosterone system during dietary sodium restriction. Five normal white male volunteer subjects were studied in metabolic balance at constant 150 meq sodium, 60 meq potassium intake, and then daily for 7 days on an isocaloric constant diet of 10 meq sodium and 60 meq potassium/day. The subjects were studied once during administration of bromocriptine and again in the presence of bromocriptine placebo. After a stepwise daily decrease in urinary sodium excretion, sodium balance was achieved on the sixth day of low sodium intake. Renal sodium conservation in response to dietary sodium restriction was associated with parallel increases in PRA, plasma aldosterone concentration, and urinary aldosterone excretion. These changes were not significantly different during placebo and bromocriptine administration. Bromocriptine was active at the pituitary dopamine receptor, as serum PRL concentrations were suppressed to undetectable levels. The results indicate that bromocriptine does not alter the response of the renin-angiotensin-aldosterone system to sodium restriction.
Authors:
R M Carey; G R Van Loon
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  55     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  162-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood*,  urine
Bromocriptine / pharmacology*
Diet, Sodium-Restricted*
Humans
Male
Natriuresis / drug effects
Prolactin / blood
Renin / blood
Renin-Angiotensin System / drug effects*
Grant Support
ID/Acronym/Agency:
HL-22306/HL/NHLBI NIH HHS; RR-847/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
25614-03-3/Bromocriptine; 52-39-1/Aldosterone; 9002-62-4/Prolactin; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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