Document Detail

Bromocriptine increased operant responding for high fat food but decreased chow intake in both obesity-prone and resistant rats.
MedLine Citation:
PMID:  21034777     Owner:  NLM     Status:  MEDLINE    
Dopamine (DA) and DA D₂ receptors (D2R) have been implicated in obesity and are thought to be involved in the rewarding properties of food. Osborne-Mendel (OM) rats are susceptible to diet induced obesity (DIO) while S5B/P (S5B) rats are resistant when given a high-fat diet. Here we hypothesized that the two strains would differ in high-fat food self-administration (FSA) and that the D2R agonist bromocriptine (BC) would differently affect their behavior. Ad-libitum fed OM and S5B/P rats were tested in a FSA operant chamber and were trained to lever press for high-fat food pellets under a fixed-ratio (FR1) and a progressive ratio (PR) schedule. After sixteen days of PR sessions, rats were treated with three different doses of BC (1, 10 and 20 mg/kg). No significant differences were found between the two strains in the number of active lever presses. BC treatment (10 mg/kg and 20 mg/kg) increased the number of active lever presses (10 mg/kg having the strongest effect) whereas it decreased rat chow intake in the home cage with equivalent effects in both strains. These effects were not observed on the day of BC administration but on the day following its administration. Our results suggest that these two strains have similar motivation for procuring high fat food using this paradigm. BC increased operant responding for high-fat pellets but decreased chow intake in both strains, suggesting that D2R stimulation may have enhanced the motivational drive to procure the fatty food while correspondingly decreasing the intake of regular food. These findings suggest that susceptibility to dietary obesity (prior to the onset of obesity) may not affect operant motivation for a palatable high fat food and that differential susceptibility to obesity may be related to differential sensitivity to D2R stimulation.
Panayotis K Thanos; Jacob Cho; Ronald Kim; Michael Michaelides; Stefany Primeaux; George Bray; Gene-Jack Wang; Nora D Volkow
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-10-27
Journal Detail:
Title:  Behavioural brain research     Volume:  217     ISSN:  1872-7549     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-04-01     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Copyright Information:
Copyright © 2010. Published by Elsevier B.V.
Laboratory of Neuroimaging, NIAAA, NIH, Department of Health and Human Services, Bethesda, MD, USA.
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MeSH Terms
Bromocriptine / pharmacology*
Conditioning, Operant / drug effects*
Dietary Fats / administration & dosage,  pharmacology*
Dose-Response Relationship, Drug
Eating / drug effects*
Rats, Inbred Strains
Reinforcement Schedule
Self Administration
Species Specificity
Grant Support
Reg. No./Substance:
0/Dietary Fats; 25614-03-3/Bromocriptine

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