Document Detail


Brominated flame retardants and perfluorinated chemicals, two groups of persistent contaminants in Belgian human blood and milk.
MedLine Citation:
PMID:  20573431     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the exposure of the Flemish population to brominated flame retardants (BFRs) and perfluorinated compounds (PFCs) by analysis of pooled cord blood, adolescent and adult serum, and human milk. Levels of polybrominated diphenyl ethers (PBDEs) in blood (range 1.6-6.5 ng/g lipid weight, lw) and milk (range 2.0-6.4 ng/g lw) agreed with European data. Hexabromocyclododecane ranged between <2.1-5.7 ng/g lw in milk. Perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) dominated in blood and ranged between 1 and 171 ng/mL and <0.9-9.5 ng/mL, respectively. Total PFC levels in milk ranged between <0.5-29 ng/mL. A significant increase in PBDE concentrations was detected from newborns (median 2.1) to the adolescents and adults (medians 3.8 and 4.6 ng/g lw, respectively). An identical trend was observed for PFOS, but not for PFOA. We estimated that newborn exposure to BFRs and PFCs occurs predominantly post-natally, whereas placental transfer has a minor impact on the body burden.
Authors:
Laurence Roosens; Wendy D'Hollander; Lieven Bervoets; Hans Reynders; Karen Van Campenhout; Christa Cornelis; Rosette Van Den Heuvel; Gudrun Koppen; Adrian Covaci
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-06-22
Journal Detail:
Title:  Environmental pollution (Barking, Essex : 1987)     Volume:  158     ISSN:  1873-6424     ISO Abbreviation:  Environ. Pollut.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804476     Medline TA:  Environ Pollut     Country:  England    
Other Details:
Languages:  eng     Pagination:  2546-52     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Toxicological Centre, Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Alkanesulfonic Acids / blood,  metabolism
Belgium
Environmental Exposure / analysis,  statistics & numerical data
Environmental Monitoring
Environmental Pollutants / blood,  metabolism*
Environmental Pollution / statistics & numerical data
Female
Fetal Blood / metabolism
Flame Retardants / metabolism*
Fluorocarbons / blood,  metabolism
Halogenated Diphenyl Ethers / blood,  metabolism
Humans
Hydrocarbons, Brominated / blood,  metabolism*
Hydrocarbons, Fluorinated / blood,  metabolism*
Infant, Newborn
Male
Middle Aged
Milk, Human / metabolism*
Octanoic Acids / blood,  metabolism
Young Adult
Chemical
Reg. No./Substance:
0/Alkanesulfonic Acids; 0/Environmental Pollutants; 0/Flame Retardants; 0/Fluorocarbons; 0/Halogenated Diphenyl Ethers; 0/Hydrocarbons, Brominated; 0/Hydrocarbons, Fluorinated; 0/Octanoic Acids; 1763-23-1/perfluorooctane sulfonic acid; 25637-99-4/hexabromocyclododecane; 335-67-1/perfluorooctanoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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