| Broad tuning of the human bitter taste receptor hTAS2R46 to various sesquiterpene lactones, clerodane and labdane diterpenoids, strychnine, and denatonium. | |
| | |
MedLine Citation:
|
PMID: 17595105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Sesquiterpene lactones are a major class of natural bitter compounds occurring in vegetables and culinary herbs as well as in aromatic and medicinal plants, where they often represent the main gustatory and pharmacologically active component. Investigations on sesquiterpene lactones have mainly focused on their bioactive potential rather than on their sensory properties. In the present study, we report about the stimulation of heterologously expressed human bitter taste receptors, hTAS2Rs, by the bitter sesquiterpene lactone herbolide D. A specific response to herbolide D was observed i.a. for hTAS2R46, a so far orphan bitter taste receptor without any known ligand. By further investigation of its agonist pattern, we characterized hTAS2R46 as a bitter receptor broadly tuned to sesquiterpene lactones and to clerodane and labdane diterpenoids as well as to the unrelated bitter substances strychnine and denatonium. |
| | |
Authors:
|
Anne Brockhoff; Maik Behrens; Alberto Massarotti; Giovanni Appendino; Wolfgang Meyerhof |
Related Documents
:
|
8670715 - Neuromodulation of transduction and signal processing in the end organs of taste. 15703335 - Five types of olfactory receptor neurons in the strawberry blossom weevil anthonomus ru... 11584075 - Scopolamine enhances generalization between odor representations in rat olfactory cortex. 8001145 - Topographic organization of sensory projections to the olfactory bulb. 22041555 - Involvement of estrogen receptors in the resveratrol-mediated increase in dopamine tran... 10363825 - 5-hydroxytryptamine2a receptor stimulation induces activator protein-1 and cyclic amp-r... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-27 |
Journal Detail:
|
Title: Journal of agricultural and food chemistry Volume: 55 ISSN: 0021-8561 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-07-19 Completed Date: 2007-10-09 Revised Date: 2007-10-18 |
Medline Journal Info:
|
Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
|
Languages: eng Pagination: 6236-43 Citation Subset: IM |
Affiliation:
|
Department of Molecular Genetics, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Diterpenes
/
pharmacology* Diterpenes, Clerodane / pharmacology Dose-Response Relationship, Drug Gene Expression / drug effects Humans Lactones / pharmacology Quaternary Ammonium Compounds / pharmacology* Receptors, G-Protein-Coupled / drug effects*, genetics Sesquiterpenes / pharmacology* Strychnine / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Diterpenes; 0/Diterpenes, Clerodane; 0/Lactones; 0/Quaternary Ammonium Compounds; 0/Receptors, G-Protein-Coupled; 0/Sesquiterpenes; 0/labdane; 0/taste receptors, type 2; 3734-33-6/denatonium benzoate; 57-24-9/Strychnine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Discrimination of wild and cultured european sea bass (Dicentrarchus labrax) using chemical and isot...
Next Document: Differentiation of green, white, black, Oolong, and Pu-erh teas according to their free amino acids ...