| Broad relays hormone signals to regulate stem cell differentiation in Drosophila midgut during metamorphosis. | |
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MedLine Citation:
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PMID: 23048182 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Like the mammalian intestine, the Drosophila adult midgut is constantly replenished by multipotent intestinal stem cells (ISCs). Although it is well known that adult ISCs arise from adult midgut progenitors (AMPs), relatively little is known about the mechanisms that regulate AMP specification. Here, we demonstrate that Broad (Br)-mediated hormone signaling regulates AMP specification. Br is highly expressed in AMPs temporally during the larva-pupa transition stage, and br loss of function blocks AMP differentiation. Furthermore, Br is required for AMPs to develop into functional ISCs. Conversely, br overexpression drives AMPs toward premature differentiation. In addition, we found that Br and Notch (N) signaling function in parallel pathways to regulate AMP differentiation. Our results reveal a molecular mechanism whereby Br-mediated hormone signaling directly regulates stem cells to generate adult cells during metamorphosis. |
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Authors:
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Xiankun Zeng; Steven X Hou |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 139 ISSN: 1477-9129 ISO Abbreviation: Development Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-10-10 Completed Date: 2012-12-20 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: England |
Other Details:
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Languages: eng Pagination: 3917-25 Citation Subset: IM |
Affiliation:
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The Mouse Cancer Genetics Program, Frederick National Laboratory for Cancer Research, National Institutes of Health, Frederick, MD 21702, USA. zengx2@mail.nih.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / genetics, physiology* Drosophila Drosophila Proteins / genetics, metabolism* Gastrointestinal Tract / cytology, metabolism* Metamorphosis, Biological / genetics, physiology Receptors, Notch / genetics, metabolism Signal Transduction / genetics, physiology Stem Cells / cytology*, metabolism Transcription Factors / genetics, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Receptors, Notch; 0/Transcription Factors; 0/broad protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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