Document Detail

Broad applicability of ultrarapid train stimulation as an efficient alternative to conventional programmed electrical stimulation.
MedLine Citation:
PMID:  12687882     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND STUDY OBJECTIVE: Conventional programmed electrical stimulation (PES) is useful for establishing inducibility or noninducibility of clinical ventricular arrhythmias (VA), but is complex and time-consuming. This study compared a standard PES protocol with ultrarapid train stimulation (UTS) in a broad range of patients with and without a history of ventricular arrhythmias or structural heart disease. METHODS: Patients prospectively underwent electrophysiologic testing with both UTS and conventional PES protocols in a randomized, crossover design. RESULTS: The results were concordant in 79% of 150 matched pairs of comparisons in 104 patients (NS). There were no differences related to underlying heart disease or arrhythmia, or antiarrhythmic treatment. Induction of nonclinical arrhythmias with the two methods was similar (P = 0.524). Inhibition phenomena were minor except in some patients receiving amiodarone. Fewer drive-extrastimuli sequences and less time were needed to complete the trains protocol (P < 0.0001). CONCLUSIONS: In cases where the main intent is to induce ventricular arrhythmias, UTS yields results that are similar to those of conventional PES protocols in a shorter length of time.
John D Fisher; Simie B Platt; Mark C Cua; Lawrence E Waspe; Soo G Kim; Kevin J Ferrick; Jay N Gross; James A Roth
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  26     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-04-11     Completed Date:  2003-07-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  518-23     Citation Subset:  IM    
Department of Medicine, Division of Cardiology, Arrhythmia Service, Montefiore Medical Center, Albert Einstein College of Medicine, 111 East 210th Street, Bronx, New York 10467, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Cardiac Pacing, Artificial / methods*
Cross-Over Studies
Electrophysiologic Techniques, Cardiac*
Middle Aged
Prospective Studies
Refractory Period, Electrophysiological
Reproducibility of Results
Tachycardia, Ventricular / physiopathology
Ventricular Fibrillation / physiopathology
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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