Document Detail

Brk regulates wing disc growth in part via repression of Myc expression.
MedLine Citation:
PMID:  23337628     Owner:  NLM     Status:  MEDLINE    
The molecular mechanisms regulating tissue size represent an unsolved puzzle in developmental biology. One signalling pathway controlling growth of the Drosophila wing is Dpp. Dpp promotes growth by repression of the transcription factor Brk. The transcriptional targets of Brk that control cell growth and proliferation, however, are not yet fully elucidated. We report here a genome-wide ChIP-Seq of endogenous Brk from wing imaginal discs. We identify the growth regulator Myc as a target of Brk and show that repression of Myc and of the miRNA bantam explains a significant fraction of the growth inhibition caused by Brk. This work sheds light on the effector mechanisms by which Dpp signalling controls tissue growth.
Nikolaos Doumpas; Marina Ruiz-Romero; Enrique Blanco; Bruce Edgar; Montserrat Corominas; Aurelio A Teleman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-22
Journal Detail:
Title:  EMBO reports     Volume:  14     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-15     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
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MeSH Terms
DNA-Binding Proteins / genetics,  metabolism*
Drosophila / genetics,  growth & development,  metabolism
Drosophila Proteins / genetics,  metabolism*
Gene Expression Regulation, Developmental*
Genome, Insect / genetics
Imaginal Discs / growth & development,  metabolism
MicroRNAs / metabolism
Repressor Proteins / genetics,  metabolism*
Transcription Factors / genetics,  metabolism*
Transcription, Genetic*
Wing / growth & development*,  metabolism
Grant Support
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/MicroRNAs; 0/Repressor Proteins; 0/Transcription Factors; 0/bantam microRNA, Drosophila; 0/brinker protein, Drosophila; 0/diminutive protein, Drosophila; 0/dpp protein, Drosophila

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