Document Detail


Brk regulates wing disc growth in part via repression of Myc expression.
MedLine Citation:
PMID:  23337628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The molecular mechanisms regulating tissue size represent an unsolved puzzle in developmental biology. One signalling pathway controlling growth of the Drosophila wing is Dpp. Dpp promotes growth by repression of the transcription factor Brk. The transcriptional targets of Brk that control cell growth and proliferation, however, are not yet fully elucidated. We report here a genome-wide ChIP-Seq of endogenous Brk from wing imaginal discs. We identify the growth regulator Myc as a target of Brk and show that repression of Myc and of the miRNA bantam explains a significant fraction of the growth inhibition caused by Brk. This work sheds light on the effector mechanisms by which Dpp signalling controls tissue growth.
Authors:
Nikolaos Doumpas; Marina Ruiz-Romero; Enrique Blanco; Bruce Edgar; Montserrat Corominas; Aurelio A Teleman
Related Documents :
23408518 - Molecular cloning, tissue distribution, and ontogenetic expression of ghrelin and regul...
24683008 - Expression of cytoskeleton regulatory protein mena in human hepatocellular carcinoma an...
25104358 - The transcription factor gli1 modulates the inflammatory response during pancreatic tis...
24992958 - Cyclooxygenase-2 inhibition as a strategy for treating gastric adenocarcinoma.
19550128 - Expression of cxcl12/cxcr4 and its correlation to prognosis in esophageal squamous cell...
15670838 - Extracellular copper ions regulate cellular prion protein (prpc) expression and metabol...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-22
Journal Detail:
Title:  EMBO reports     Volume:  14     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-08-15     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  261-8     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
DNA-Binding Proteins / genetics,  metabolism*
Down-Regulation
Drosophila / genetics,  growth & development,  metabolism
Drosophila Proteins / genetics,  metabolism*
Gene Expression Regulation, Developmental*
Genome, Insect / genetics
Imaginal Discs / growth & development,  metabolism
MicroRNAs / metabolism
Repressor Proteins / genetics,  metabolism*
Transcription Factors / genetics,  metabolism*
Transcription, Genetic*
Wing / growth & development*,  metabolism
Grant Support
ID/Acronym/Agency:
R01 GM51186/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/MicroRNAs; 0/Repressor Proteins; 0/Transcription Factors; 0/bantam microRNA, Drosophila; 0/brinker protein, Drosophila; 0/diminutive protein, Drosophila; 0/dpp protein, Drosophila
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Non-autophagic roles of autophagy-related proteins.
Next Document:  Transdermal Drug Delivery of Paroxetine through Lipid-Vesicular Formulation to augment its Bioavaila...