| Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension. | |
| | |
MedLine Citation:
|
PMID: 15205246 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: To evaluate the efficacy of brimonidine purite versus dorzolamide given twice daily in primary open angle glaucoma or ocular hypertensive subjects. METHODS: In this double masked, multicentre, prospective, crossover comparison 33 subjects were randomised to brimonidine purite or dorzolamide for the first 4 week treatment period after a 4 week washout. Subjects began the opposite treatment for the second 4 week period after another 4 week washout. Intraocular pressure (IOP) was measured at 08:00 (trough) and 10:00, 18:00, and 20:00 hours after dosing at each baseline and at the end of each treatment period. RESULTS: The baseline diurnal IOP was 22.9 (SD 2.8) for brimonidine purite and 22.2 (SD 2.4) mm Hg for dorzolamide. The trough IOP following 4 weeks of therapy was 21.0 (SD 3.7) for brimonidine purite and 21.0 (SD 3.1) mm Hg for dorzolamide (p = 0.90). The mean diurnal IOP was 19.3 (SD 3.1) for brimonidine purite and 19.8 (SD 2.4) mm Hg for dorzolamide (p = 0.46). Dorzolamide caused more ocular stinging upon instillation (n = 8) than brimonidine purite (n = 1) (p = 0.02). No statistical differences existed between groups for systemic adverse events. CONCLUSIONS: This study suggests that brimonidine purite and dorzolamide each given twice daily have similar efficacy in primary open angle glaucoma or ocular hypertensive subjects. However, a trend was observed at 10:00 of greater brimonidine purite efficacy compared with dorzolamide. |
| | |
Authors:
|
E D Sharpe; D G Day; C J Beischel; J S Rhodes; J A Stewart; W C Stewart |
Related Documents
:
|
19684006 - Twenty-four hour (nyctohemeral) rhythm of intraocular pressure and ocular perfusion pre... 19450446 - Acute retinal ischemia caused by controlled low ocular perfusion pressure in a porcine ... 19382536 - Pathophysiology of glaucoma and continuous measurements of intraocular pressure. 16544116 - Changes in glaucoma treatment and achieved iop after introduction of new glaucoma medic... 17733286 - Local structure and chemical shifts for six-coordinated silicon in high-pressure mantle... 23048186 - Chronic treatment with a melanocortin-4 receptor agonist causes weight loss, reduces in... |
Publication Detail:
|
Type: Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The British journal of ophthalmology Volume: 88 ISSN: 0007-1161 ISO Abbreviation: Br J Ophthalmol Publication Date: 2004 Jul |
Date Detail:
|
Created Date: 2004-06-18 Completed Date: 2004-07-27 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
|
Languages: eng Pagination: 953-6 Citation Subset: IM |
Affiliation:
|
Opthalmology Consultants, Mt Pleasant, SC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antihypertensive Agents
/
administration & dosage*,
adverse effects Cross-Over Studies Double-Blind Method Drug Administration Schedule Female Glaucoma, Open-Angle / drug therapy* Humans Intraocular Pressure / drug effects* Male Middle Aged Ocular Hypertension / drug therapy* Prospective Studies Quinoxalines / administration & dosage*, adverse effects Sulfonamides / administration & dosage*, adverse effects Thiophenes / administration & dosage*, adverse effects |
| Chemical | |
Reg. No./Substance:
|
0/Antihypertensive Agents; 0/Quinoxalines; 0/Sulfonamides; 0/Thiophenes; 130693-82-2/dorzolamide; 59803-98-4/brimonidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes.
Next Document: Conditioned medium from mixed retinal pigmented epithelium and Müller cell cultures reduces in vitr...