Document Detail

Brimonidine purite 0.15% versus dorzolamide 2% each given twice daily to reduce intraocular pressure in subjects with open angle glaucoma or ocular hypertension.
MedLine Citation:
PMID:  15205246     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: To evaluate the efficacy of brimonidine purite versus dorzolamide given twice daily in primary open angle glaucoma or ocular hypertensive subjects.
METHODS: In this double masked, multicentre, prospective, crossover comparison 33 subjects were randomised to brimonidine purite or dorzolamide for the first 4 week treatment period after a 4 week washout. Subjects began the opposite treatment for the second 4 week period after another 4 week washout. Intraocular pressure (IOP) was measured at 08:00 (trough) and 10:00, 18:00, and 20:00 hours after dosing at each baseline and at the end of each treatment period.
RESULTS: The baseline diurnal IOP was 22.9 (SD 2.8) for brimonidine purite and 22.2 (SD 2.4) mm Hg for dorzolamide. The trough IOP following 4 weeks of therapy was 21.0 (SD 3.7) for brimonidine purite and 21.0 (SD 3.1) mm Hg for dorzolamide (p = 0.90). The mean diurnal IOP was 19.3 (SD 3.1) for brimonidine purite and 19.8 (SD 2.4) mm Hg for dorzolamide (p = 0.46). Dorzolamide caused more ocular stinging upon instillation (n = 8) than brimonidine purite (n = 1) (p = 0.02). No statistical differences existed between groups for systemic adverse events.
CONCLUSIONS: This study suggests that brimonidine purite and dorzolamide each given twice daily have similar efficacy in primary open angle glaucoma or ocular hypertensive subjects. However, a trend was observed at 10:00 of greater brimonidine purite efficacy compared with dorzolamide.
E D Sharpe; D G Day; C J Beischel; J S Rhodes; J A Stewart; W C Stewart
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  88     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-18     Completed Date:  2004-07-27     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  England    
Other Details:
Languages:  eng     Pagination:  953-6     Citation Subset:  IM    
Opthalmology Consultants, Mt Pleasant, SC, USA.
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MeSH Terms
Antihypertensive Agents / administration & dosage*,  adverse effects
Cross-Over Studies
Double-Blind Method
Drug Administration Schedule
Glaucoma, Open-Angle / drug therapy*
Intraocular Pressure / drug effects*
Middle Aged
Ocular Hypertension / drug therapy*
Prospective Studies
Quinoxalines / administration & dosage*,  adverse effects
Sulfonamides / administration & dosage*,  adverse effects
Thiophenes / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Antihypertensive Agents; 0/Quinoxalines; 0/Sulfonamides; 0/Thiophenes; 59803-98-4/brimonidine; 9JDX055TW1/dorzolamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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