Document Detail

Brief occlusion of the main pancreatic duct rapidly initiates signals which lead to increased duct cell proliferation in the rat.
MedLine Citation:
PMID:  11237414     Owner:  NLM     Status:  MEDLINE    
In the course of investigating the signals associated with pancreas regeneration, we have developed a method to initiate pancreatic duct cell proliferation by brief occlusion of the main pancreatic duct. The resulting duct cell proliferation, induced by temporary partial main duct occlusion, was compared to that induced by firmly tying a cellophane strip around the head of the pancreas for longer periods of time. Both methods stimulated a biphasic increase in duct cell proliferation, with proliferation maxima at 3 and 14 days post operation. The short duration of temporary main duct occlusion (60 s) that was needed to stimulate duct cell proliferation, and the similar duct cell proliferation profiles that were observed after both the temporary and the longer term main duct occlusion, led us to conclude that the signals which initiate proliferation occur rapidly at the beginning of each procedure.
W F Ferris; C W Woodroof; J Louw; S A Wolfe-Coote
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell biology international     Volume:  25     ISSN:  1065-6995     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-21     Completed Date:  2001-05-21     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Experimental Biology Programme, Medical Research Council, Tygerberg 7505, South Africa.
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MeSH Terms
Amylases / blood
Blood Glucose / metabolism
Cell Division
Ki-67 Antigen / biosynthesis
Pancreatic Ducts / cytology*,  pathology,  surgery*
Pancreatitis / metabolism,  pathology
Rats, Wistar
Time Factors
Reg. No./Substance:
0/Blood Glucose; 0/Ki-67 Antigen; 9005-81-6/Cellophane; EC 3.2.1.-/Amylases

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