| Brief myocardial ischemia attenuates platelet thrombosis in remote, damaged, and stenotic carotid arteries. | |
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MedLine Citation:
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PMID: 10458721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Brief antecedent periods of coronary artery occlusion improve subsequent vessel patency in damaged and stenotic coronary arteries via release of adenosine from ischemic/reperfused myocardium and resultant adenosine receptor stimulation. However, the site of receptor stimulation-circulating blood-borne elements (ie, platelets) versus vessel-wall components of the culprit artery-remains unclear. If platelet adenosine receptors are involved, then the benefits of brief coronary occlusion (1) should be manifested systemically and improve patency at a remote site and (2) should be inhibited by an antagonist of adenosine A(2) receptors, whereas, in contrast, (3) brief vascular occlusion not associated with appreciable adenosine release should be ineffective in improving vessel patency. METHODS AND RESULTS: In Protocol 1, anesthetized rabbits received 5 minutes of transient coronary occlusion, 5 minutes of transient bilateral carotid occlusion (purported to cause negligible adenosine release from the brain), or no intervention. All rabbits then underwent injury plus stenosis of the left carotid artery, resulting in repeated cyclic variations in carotid blood flow (CFVs). Carotid patency during the initial 2 hours after stenosis (assessed by quantifying the nadir of the CFVs and area of the flow-time profile) was significantly enhanced with antecedent coronary-but not carotid-occlusion versus controls. In Protocol 2, improvement in carotid patency after brief coronary occlusion was corroborated in anesthetized dogs. However, the benefits of brief coronary occlusion were abrogated by the A(2)/A(1) antagonist CGS 15943. CONCLUSIONS: Brief antecedent coronary artery occlusion enhanced vessel patency in remote, damaged, and stenotic carotid arteries, largely due to adenosine receptor stimulation on circulating elements. |
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Authors:
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K Hata; P Whittaker; R A Kloner; K Przyklenk |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation Volume: 100 ISSN: 1524-4539 ISO Abbreviation: Circulation Publication Date: 1999 Aug |
Date Detail:
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Created Date: 1999-09-13 Completed Date: 1999-09-13 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 843-8 Citation Subset: AIM; IM |
Affiliation:
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Heart Institute, Good Samaritan Hospital, Department of Medicine University of Southern California, Los Angeles, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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antagonists & inhibitors,
secretion Animals Blood Platelets / pathology Carotid Artery Thrombosis / pathology* Carotid Stenosis / pathology* Dogs Myocardial Ischemia / pathology* Quinazolines / pharmacology Rabbits Receptors, Purinergic P1 / physiology Triazoles / pharmacology Vascular Patency |
| Chemical | |
Reg. No./Substance:
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0/Quinazolines; 0/Receptors, Purinergic P1; 0/Triazoles; 104615-18-1/9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine; 58-61-7/Adenosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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