Document Detail

Brief food restriction in old animals decreases triglyceride content and insulin-stimulated triglyceride synthesis.
MedLine Citation:
PMID:  15814856     Owner:  NLM     Status:  MEDLINE    
To determine the effects of brief food restriction on fatty acid (FA) metabolism in old muscle, hind limbs of 24-month F344/BN rats fed either ad libitum (AL) or 60% food restricted (FR) for 28 days were perfused under hyperglycemic-hyperinsulinemic conditions. Basal glucose and insulin levels were significantly lower (p<.05) in FR rats. Although palmitate uptake was not affected by food restriction, palmitate oxidation was 49% lower (2.2+/-0.3 vs 4.3+/-0.7 nmol . g-1 . min-1, p<.05) in FR versus AL animals, respectively. Compared to AL animals, FR animals had 25%-43% (p<.05) lower muscle triglyceride (TG) levels and hyperinsulinemic TG synthesis rates. Higher glucose uptake rates occurred in FR rats (p<.05). In conclusion, our results indicate that brief food restriction in old animals improves insulin sensitivity as it pertains to both glucose uptake and FA oxidation. Together with the decrease in nonoxidative FA disposal, the decreased FA oxidation under hyperinsulinemic conditions may significantly contribute to food restriction-induced reduction in muscle TG.
Michelle Z Tucker; Lorraine P Turcotte
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  60     ISSN:  1079-5006     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-04-07     Completed Date:  2005-06-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  157-64     Citation Subset:  AIM; IM    
Department of Kinesiology, University of Southern California, 3560 Watt Way, PED 107, Los Angeles, CA 90089-0652, USA.
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MeSH Terms
Aging / physiology*
Blotting, Western
Fatty Acids / metabolism
Food Deprivation / physiology*
Insulin / physiology*
Muscle, Skeletal / metabolism
Palmitic Acid / metabolism
Rats, Inbred BN
Rats, Inbred F344
Triglycerides / analysis*,  biosynthesis
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Triglycerides; 11061-68-0/Insulin; 57-10-3/Palmitic Acid

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