| Brief food restriction in old animals decreases triglyceride content and insulin-stimulated triglyceride synthesis. | |
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MedLine Citation:
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PMID: 15814856 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine the effects of brief food restriction on fatty acid (FA) metabolism in old muscle, hind limbs of 24-month F344/BN rats fed either ad libitum (AL) or 60% food restricted (FR) for 28 days were perfused under hyperglycemic-hyperinsulinemic conditions. Basal glucose and insulin levels were significantly lower (p<.05) in FR rats. Although palmitate uptake was not affected by food restriction, palmitate oxidation was 49% lower (2.2+/-0.3 vs 4.3+/-0.7 nmol . g-1 . min-1, p<.05) in FR versus AL animals, respectively. Compared to AL animals, FR animals had 25%-43% (p<.05) lower muscle triglyceride (TG) levels and hyperinsulinemic TG synthesis rates. Higher glucose uptake rates occurred in FR rats (p<.05). In conclusion, our results indicate that brief food restriction in old animals improves insulin sensitivity as it pertains to both glucose uptake and FA oxidation. Together with the decrease in nonoxidative FA disposal, the decreased FA oxidation under hyperinsulinemic conditions may significantly contribute to food restriction-induced reduction in muscle TG. |
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Authors:
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Michelle Z Tucker; Lorraine P Turcotte |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The journals of gerontology. Series A, Biological sciences and medical sciences Volume: 60 ISSN: 1079-5006 ISO Abbreviation: J. Gerontol. A Biol. Sci. Med. Sci. Publication Date: 2005 Feb |
Date Detail:
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Created Date: 2005-04-07 Completed Date: 2005-06-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9502837 Medline TA: J Gerontol A Biol Sci Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 157-64 Citation Subset: AIM; IM |
Affiliation:
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Department of Kinesiology, University of Southern California, 3560 Watt Way, PED 107, Los Angeles, CA 90089-0652, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Blotting, Western Fatty Acids / metabolism Food Deprivation / physiology* Insulin / physiology* Male Muscle, Skeletal / metabolism Palmitic Acid / metabolism Rats Rats, Inbred BN Rats, Inbred F344 Triglycerides / analysis*, biosynthesis |
| Grant Support | |
ID/Acronym/Agency:
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AR-45168/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Triglycerides; 11061-68-0/Insulin; 57-10-3/Palmitic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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