| Brief early handling increases morphine dependence in adult rats. | |
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MedLine Citation:
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PMID: 16567006 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Short early manipulations of rodent postnatal environment may trigger long-term effects on neurobiological and behavioural phenotypes in adulthood. However, little is known about such effects of handling on the vulnerability to develop drug dependence. The present study aimed to analyze the long-term effects of a brief handling (1 min) on morphine and ethanol dependence and on the preproenkephalin (PPE) mRNA and mu opioid receptor levels. Handled rats showed a significant increase in morphine (25mg/l) but not ethanol (10%) consumption and preference after 7 weeks and no difference in morphine (2 and 5mg/kg) conditioned place preference. No difference of preproenkephalin mRNA and mu opioid receptor levels was detected in the mesolimbic system between both groups. These data emphasize that human brief handling, which can lead to morphine dependence development, constitutes in itself an experimental treatment and not a control condition. |
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Authors:
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Vincent Vazquez; Jacqueline Penit-Soria; Claudette Durand; Marie-Jo Besson; Bruno Giros; Valérie Daugé |
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Publication Detail:
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Type: Comparative Study; Journal Article Date: 2006-03-29 |
Journal Detail:
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Title: Behavioural brain research Volume: 170 ISSN: 0166-4328 ISO Abbreviation: Behav. Brain Res. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-22 Completed Date: 2006-09-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 211-8 Citation Subset: IM |
Affiliation:
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INSERM, U513, Créteil, F-94010 France; Université Paris XII, Créteil, F-94010 France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Autoradiography / methods Behavior, Animal Central Nervous System Depressants / adverse effects Conditioning, Operant / drug effects, physiology Endothelin-1 / genetics, metabolism Ethanol / adverse effects Female Gene Expression / drug effects Handling (Psychology)* In Situ Hybridization / methods Male Morphine / adverse effects* Morphine Dependence* / etiology, metabolism, physiopathology Narcotics / adverse effects* Pregnancy RNA, Messenger / metabolism Rats Receptors, Opioid, mu / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Endothelin-1; 0/Narcotics; 0/RNA, Messenger; 0/Receptors, Opioid, mu; 57-27-2/Morphine; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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