Document Detail


Brief daily periods of unrestricted vision can prevent form-deprivation amblyopia.
MedLine Citation:
PMID:  16723458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To characterize how the mechanisms that produce unilateral form-deprivation amblyopia integrate the effects of normal and abnormal vision over time, the effects of brief daily periods of unrestricted vision on the spatial vision losses produced by monocular form deprivation were investigated in infant monkeys.
METHODS: Beginning at 3 weeks of age, unilateral form deprivation was initiated in 18 infant monkeys by securing a diffuser spectacle lens in front of one eye and a clear plano lens in front of the fellow eye. During the treatment period (18 weeks), three infants wore the diffusers continuously. For the other experimental infants, the diffusers were removed daily and replaced with clear, zero-powered lenses for 1 (n=5), 2 (n=6), or 4 (n=4) hours. Four infants reared with binocular zero-powered lenses and four normally reared monkeys provided control data.
RESULTS: The degree of amblyopia varied significantly with the daily duration of unrestricted vision. Continuous form deprivation caused severe amblyopia. However, 1 hour of unrestricted vision reduced the degree of amblyopia by 65%, 2 hours reduced the deficits by 90%, and 4 hours preserved near-normal spatial contrast sensitivity.
CONCLUSIONS: The severely amblyogenic effects of form deprivation in infant primates are substantially reduced by relatively short daily periods of unrestricted vision. The manner in which the mechanisms responsible for amblyopia integrate the effects of normal and abnormal vision over time promotes normal visual development and has important implications for the management of human infants with conditions that potentially cause amblyopia.
Authors:
Janice M Wensveen; Ronald S Harwerth; Li-Fang Hung; Ramkumar Ramamirtham; Chea-su Kee; Earl L Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  47     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-25     Completed Date:  2006-07-03     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2468-77     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amblyopia / etiology,  prevention & control*
Animals
Animals, Newborn
Contrast Sensitivity / physiology
Disease Models, Animal
Macaca mulatta
Retina / physiology
Sensory Deprivation*
Time Factors
Vision, Ocular / physiology*
Grant Support
ID/Acronym/Agency:
P30 EY07551/EY/NEI NIH HHS; R01 EY003611-24A1/EY/NEI NIH HHS; R01 EY01139/EY/NEI NIH HHS; R01 EY03611/EY/NEI NIH HHS
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