Document Detail


Brief communication: magnesium absorption in human ileum.
MedLine Citation:
PMID:  1894878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A novel technique utilizing samples of human distal ileum removed at surgery was used to study magnesium (Mg) absorption. Specimens of isolated absorptive mucosa were obtained by careful dissection of the tissue to remove the muscle layers, and were mounted in flux chambers. Mean tissue Mg concentration in human isolated intestinal mucosa was found to be within the postulated normal range for human tissue. Mucosal to serosal Mg transport was unaffected by ouabain or 2,4-dinitrophenol and sodium fluoride. Overall, the data indicate Mg absorption in distal ileum to be passive in nature, although a minor active transcellular component cannot be excluded.
Authors:
J D Phillips; R J Davie; M R Keighley; N J Birch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Nutrition     Volume:  10     ISSN:  0731-5724     ISO Abbreviation:  J Am Coll Nutr     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8215879     Medline TA:  J Am Coll Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  200-4     Citation Subset:  IM    
Affiliation:
Biomedical Research Laboratory, School of Health Sciences, Wolverhampton Polytechnic, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
2,4-Dinitrophenol
Adolescent
Adult
Biological Transport / drug effects
Culture Techniques
Dinitrophenols / pharmacology
Female
Humans
Ileum / drug effects,  metabolism*
Intestinal Absorption* / drug effects
Intestinal Mucosa / drug effects,  metabolism*
Magnesium / pharmacokinetics*
Middle Aged
Ouabain / pharmacology
Sodium Fluoride / pharmacology
Uncoupling Agents / pharmacology
Chemical
Reg. No./Substance:
0/Dinitrophenols; 0/Uncoupling Agents; 51-28-5/2,4-Dinitrophenol; 630-60-4/Ouabain; 7439-95-4/Magnesium; 7681-49-4/Sodium Fluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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