Document Detail


Brief report: differences in multijoint symptomatic osteoarthritis phenotypes by race and sex: the Johnston County Osteoarthritis Project.
MedLine Citation:
PMID:  23359309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To determine differences in the phenotypes (patterns) of multiple-joint symptomatic osteoarthritis (OA) involvement by race and sex.
METHODS: A cross-sectional analysis of symptomatic OA phenotypes was performed in a community-based cohort, comprising subjects for whom data were collected from 4 sites of symptomatic OA involvement (the hands, knees, hips, and lumbosacral [LS] spine) at a single visit (2003-2010). Mutually exclusive phenotypes describing all combinations of these 4 sites were compared by race and by sex, using Fisher's exact tests. For those phenotypes occurring in >40 subjects, logistic regression was performed, with adjustments for race, sex, age, and body mass index (BMI), and interactions of race and sex were assessed.
RESULTS: The sample included 1,650 participants, of whom 36% were men and 32% were African American. The mean age of the subjects was 66 years, and the mean BMI was 31 kg/m(2). Overall, in this sample, 13% of subjects had symptomatic hand OA, 25% had symptomatic knee OA, 11% had symptomatic hip OA, and 28% had symptomatic LS spine OA. African Americans, as compared with Caucasians, were less likely to have involvement of symptomatic OA in the hand only, or in some combination of the hand and other sites, but were more likely to have involvement of the knee only. Men, as compared to women, were less likely to have involvement of the hand only, but were more likely to have involvement of the LS spine only.
CONCLUSION: There are differences in the phenotypes of multiple-joint symptomatic OA involvement by race and by sex that may influence the definitions of multiple-joint, or generalized, OA.
Authors:
Amanda E Nelson; Yvonne M Golightly; Jordan B Renner; Todd A Schwartz; Virginia B Kraus; Charles G Helmick; Joanne M Jordan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  65     ISSN:  1529-0131     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-29     Completed Date:  2013-04-11     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-7     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
Aged
Aged, 80 and over
Cross-Sectional Studies
European Continental Ancestry Group
Female
Humans
Longitudinal Studies
Male
Middle Aged
Osteoarthritis / diagnosis*,  ethnology
Phenotype*
Prospective Studies
Sex Factors
Grant Support
ID/Acronym/Agency:
5-P30-AG028716/AG/NIA NIH HHS; K23 AR061406/AR/NIAMS NIH HHS; K23-AR-061406/AR/NIAMS NIH HHS; P01 AR050245/AR/NIAMS NIH HHS; P01-AR-050245/AR/NIAMS NIH HHS; P30 AG028716/AG/NIA NIH HHS; P60 AR030701/AR/NIAMS NIH HHS; P60-AR-30701/AR/NIAMS NIH HHS
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