Document Detail


A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects.
MedLine Citation:
PMID:  22307907     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many chronic pulmonary diseases are associated with pulmonary hypertension (PH) and pulmonary vascular remodeling, which is a term that continues to be used to describe a wide spectrum of vascular abnormalities. Pulmonary vascular structural changes frequently increase pulmonary vascular resistance, causing PH and right heart failure. Although rat models had been standard models of PH research, in more recent years the availability of genetically engineered mice has made this species attractive for many investigators. Here we review a large amount of data derived from experimental PH reports published since 1996. These studies using wild-type and genetically designed mice illustrate the challenges and opportunities provided by these models. Hemodynamic measurements are difficult to obtain in mice, and right heart failure has not been investigated in mice. Anatomical, cellular, and genetic differences distinguish mice and rats, and pharmacogenomics may explain the degree of PH and the particular mode of pulmonary vascular adaptation and also the response of the right ventricle.
Authors:
Jose Gomez-Arroyo; Sheinei J Saleem; Shiro Mizuno; Aamer A Syed; Harm J Bogaard; Antonio Abbate; Laimute Taraseviciene-Stewart; Yon Sung; Donatas Kraskauskas; Daniela Farkas; Daniel H Conrad; Mark R Nicolls; Norbert F Voelkel
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Publication Detail:
Type:  Journal Article; Review     Date:  2012-02-03
Journal Detail:
Title:  American journal of physiology. Lung cellular and molecular physiology     Volume:  302     ISSN:  1522-1504     ISO Abbreviation:  Am. J. Physiol. Lung Cell Mol. Physiol.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-16     Completed Date:  2012-07-05     Revised Date:  2013-10-20    
Medline Journal Info:
Nlm Unique ID:  100901229     Medline TA:  Am J Physiol Lung Cell Mol Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  L977-91     Citation Subset:  IM    
Affiliation:
Victoria Johnson Center for Obstructive Lung Disease Research, Virginia Commonwealth University, 1220 E. Broad St., Richmond, VA 23298, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Disease Models, Animal*
Heart Ventricles / pathology,  physiopathology*
Hypertension, Pulmonary / pathology,  physiopathology*
Hypertrophy, Right Ventricular / pathology,  physiopathology*
Mice
Mice, Transgenic
Pulmonary Artery / pathology,  physiopathology*
Rats
Vascular Resistance
Ventricular Function, Right
Ventricular Remodeling
Grant Support
ID/Acronym/Agency:
P01 HL108797/HL/NHLBI NIH HHS; R01 HL082662/HL/NHLBI NIH HHS; R01 HL095686/HL/NHLBI NIH HHS
Comments/Corrections

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