Document Detail


A brief history of hair cell regeneration research and speculations on the future.
MedLine Citation:
PMID:  23321648     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Millions of people worldwide suffer from hearing and balance disorders caused by loss of the sensory hair cells that convert sound vibrations and head movements into electrical signals that are conveyed to the brain. In mammals, the great majority of hair cells are produced during embryogenesis. Hair cells that are lost after birth are virtually irreplaceable, leading to permanent disability. Other vertebrates, such as fish and amphibians, produce hair cells throughout life. However, hair cell replacement after damage to the mature inner ear was either not investigated or assumed to be impossible until studies in the late 1980s proved this to be false. Adult birds were shown to regenerate lost hair cells in the auditory sensory epithelium after noise- and ototoxic drug-induced damage. Since then, the field of hair cell regeneration has continued to investigate the capacity of the auditory and vestibular epithelia in vertebrates (fishes, birds, reptiles, and mammals) to regenerate hair cells and to recover function, the molecular mechanisms governing these regenerative capabilities, and the prospect of designing biologically-based treatments for hearing loss and balance disorders. Here, we review the major findings of the field during the past 25 years and speculate how future inner ear repair may one day be achieved.
Authors:
Edwin W Rubel; Stephanie A Furrer; Jennifer S Stone
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Publication Detail:
Type:  Journal Article; Review     Date:  2013-01-12
Journal Detail:
Title:  Hearing research     Volume:  297     ISSN:  1878-5891     ISO Abbreviation:  Hear. Res.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-04     Completed Date:  2013-09-27     Revised Date:  2014-03-06    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  42-51     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Transplantation / methods
Ear, Inner / physiology
Epithelium / physiopathology
Gene Expression Profiling
Gene Expression Regulation, Developmental
Hair Cells, Auditory / cytology*,  physiology*
Hearing Loss, Noise-Induced / physiopathology
Humans
Mitosis
Regeneration*
Stem Cells / cytology*
Grant Support
ID/Acronym/Agency:
F32 DC000181/DC/NIDCD NIH HHS; P30 DC004661/DC/NIDCD NIH HHS; T32 DC005361/DC/NIDCD NIH HHS
Comments/Corrections

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