Document Detail

Brick tunnel randomization for unequal allocation to two or more treatment groups.
MedLine Citation:
PMID:  21240999     Owner:  NLM     Status:  Publisher    
Studies with unequal allocation to two or more treatment groups often require a large block size for permuted block allocation. This could present a problem in small studies, multi-center studies, or adaptive design dose-finding studies. In this paper, an allocation procedure, which generalizes the maximal procedure by Berger, Ivanova, and Knoll to the case of K≥2 treatment groups and any allocation ratio, is offered. Brick tunnel (BT) randomization requires the allocation path drawn in the k-dimensional space to stay close to the allocation ray that corresponds to the targeted allocation ratio. Specifically, it requires the allocation path to be confined to the set of the k-dimensional unitary cubes that are pierced by the allocation ray (the 'brick tunnel'). The important property of the BT randomization is that the transition probabilities at each node within the tunnel are defined in such a way that the unconditional allocation ratio is the same for every allocation step. This property is not necessarily met by other allocation procedures that implement unequal allocation. Copyright © 2011 John Wiley & Sons, Ltd.
Olga M Kuznetsova; Yevgen Tymofyeyev
Related Documents :
1975819 - Ursodeoxycholic acid for the treatment of primary biliary cirrhosis. interim analysis o...
7864419 - Duration of vecuronium-induced neuromuscular block as a predictor of liver allograft dy...
20729689 - Comparison of endoscopic therapeutic modalities for postoperative biliary fistula of li...
20632449 - Transcatheter arterial chemoembolization with a fine-powder formulation of cisplatin fo...
3523799 - A two year experience with 99mtc hida cholescintigraphy in teaching hospital practice.
17653639 - Fixation of the greater omentum for prevention of delayed gastric emptying after left h...
15824219 - Outcomes of complex retinal detachment repair using 1000- vs 5000-centistoke silicone oil.
1488569 - Cardiorespiratory function in surgically treated thoracic scoliosis with respect to deg...
25069909 - Radiographic and clinical outcomes of the treatment of immature permanent teeth by reva...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-13
Journal Detail:
Title:  Statistics in medicine     Volume:  -     ISSN:  1097-0258     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8215016     Medline TA:  Stat Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Merck Sharp & Dohme Corp., 126 East Lincoln Avenue, Rahway, NJ 07065-0900, U.S.A.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Metastasis suppressors in human benign prostate, intraepithelial neoplasia, and invasive cancer: the...
Next Document:  LIM kinases are attractive targets with many macromolecular partners and only a few small molecule r...