Document Detail

Bretylium tosylate in the management of recurrent ventricular fibrillation complicating acute myocardial infarction.
MedLine Citation:
PMID:  6898604     Owner:  NLM     Status:  MEDLINE    
Eighteen patients with recurrent ventricular fibrillation complicating acute myocardial infarction were treated with bretylium tosylate. All except one patient had been given therapeutic doses of lidocaine and some, in addition, had received other antiarrhythmic agents before bretylium. Bretylium therapy was initiated with intravenous administration of 5 mg/kg body weight and was usually maintained by administering the same dose every 6 to 8 hours by intramuscular route. Ten patients recovered while eight died. Only two of the survivors exhibited heart failure and none of them was in shock, while cardiogenic shock dominated the course of patients with fatal outcome. Postural hypotension invariably occurred but without any clinical deterioration of cardiac function. It is concluded that often bretylium tosylate is an effective therapeutic agent in suppression of recurrent or resistant ventricular fibrillation.
R W Dhurandhar; J Pickron; A M Goldman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Heart & lung : the journal of critical care     Volume:  9     ISSN:  0147-9563     ISO Abbreviation:  Heart Lung     Publication Date:    1980 Mar-Apr
Date Detail:
Created Date:  1980-05-14     Completed Date:  1980-05-14     Revised Date:  2006-08-28    
Medline Journal Info:
Nlm Unique ID:  0330057     Medline TA:  Heart Lung     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  265-70     Citation Subset:  AIM; IM    
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MeSH Terms
Bretylium Compounds / therapeutic use*
Bretylium Tosylate / therapeutic use*
Middle Aged
Myocardial Infarction / complications*
Ventricular Fibrillation / drug therapy*,  etiology
Reg. No./Substance:
0/Bretylium Compounds; 61-75-6/Bretylium Tosylate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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