Document Detail


Bremazocine-induced urination in rats of different sizes.
MedLine Citation:
PMID:  3671877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increased urine output after injection of the kappa agonist bremazocine was determined in rats of various body weights. Rats of all sizes were sensitive to the diuretic effect of bremazocine. The total diuretic effect was greater in heavier animals. The urine output plateaued between 4-5 ml/100 g body weight irrespective of body weight at the higher doses of bremazocine.
Authors:
J D Leander
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  57     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-11-25     Completed Date:  1987-11-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  141-4     Citation Subset:  IM    
Affiliation:
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285.
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MeSH Terms
Descriptor/Qualifier:
Analgesics / pharmacology*
Animals
Benzomorphans / pharmacology*
Body Weight
Dose-Response Relationship, Drug
Male
Morphinans / pharmacology*
Rats
Urination / drug effects*
Chemical
Reg. No./Substance:
0/Analgesics; 0/Benzomorphans; 0/Morphinans; 75684-07-0/bremazocine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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