| Breeding and offspring rearing ability of C57BL/6J dystrophic mice. | |
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MedLine Citation:
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PMID: 6513507 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The antiepileptic drug phenytoin, administered in drinking water for 104 days, was used to reduce the neural overactivity (pseudomyotonia) of C57BL/6J dystrophic (dy2J/dy2J) male mice in an attempt to improve their breeding success over a 90-day period. Male dy2J/dy2J mice have difficulty in successfully mounting females due to the pseudomyotonia affecting their hindlimb musculature. Breeding success, as judged by litter frequency, of dy2J/dy2J males receiving phenytoin (5 micrograms/ml serum) was compared with untreated dy2J/dy2J and phenotypically normal (+/?) male and female mice. Phenytoin did not enhance male dy2J/dy2J breeding success. Based on dy2J/dy2J crosses with +/? animals, the dy2J/dy2J female was a more successful breeder than the dy2J/dy2J male. In terms of litter frequency, litter size, and offspring birth weight, dy2J/dy2J females (age 8-21 wks.) bred as efficiently as +/? females of the same age. Dystrophic females were deficient in offspring rearing capabilities as evidenced by lower offspring survival rates and weaning weights. |
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Authors:
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L E Younger; H Silverman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Laboratory animal science Volume: 34 ISSN: 0023-6764 ISO Abbreviation: Lab. Anim. Sci. Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1985-01-25 Completed Date: 1985-01-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266503 Medline TA: Lab Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 471-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breeding* Crosses, Genetic Female Male Mice Mice, Inbred Strains* / genetics Muscular Dystrophy, Animal / drug therapy, physiopathology* Phenytoin / pharmacology Reproduction* / drug effects Rodent Diseases / drug therapy, physiopathology* Sexual Behavior, Animal / drug effects |
| Chemical | |
Reg. No./Substance:
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57-41-0/Phenytoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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