Document Detail

Breeding and offspring rearing ability of C57BL/6J dystrophic mice.
MedLine Citation:
PMID:  6513507     Owner:  NLM     Status:  MEDLINE    
The antiepileptic drug phenytoin, administered in drinking water for 104 days, was used to reduce the neural overactivity (pseudomyotonia) of C57BL/6J dystrophic (dy2J/dy2J) male mice in an attempt to improve their breeding success over a 90-day period. Male dy2J/dy2J mice have difficulty in successfully mounting females due to the pseudomyotonia affecting their hindlimb musculature. Breeding success, as judged by litter frequency, of dy2J/dy2J males receiving phenytoin (5 micrograms/ml serum) was compared with untreated dy2J/dy2J and phenotypically normal (+/?) male and female mice. Phenytoin did not enhance male dy2J/dy2J breeding success. Based on dy2J/dy2J crosses with +/? animals, the dy2J/dy2J female was a more successful breeder than the dy2J/dy2J male. In terms of litter frequency, litter size, and offspring birth weight, dy2J/dy2J females (age 8-21 wks.) bred as efficiently as +/? females of the same age. Dystrophic females were deficient in offspring rearing capabilities as evidenced by lower offspring survival rates and weaning weights.
L E Younger; H Silverman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Laboratory animal science     Volume:  34     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1984 Oct 
Date Detail:
Created Date:  1985-01-25     Completed Date:  1985-01-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-4     Citation Subset:  IM    
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MeSH Terms
Crosses, Genetic
Mice, Inbred Strains* / genetics
Muscular Dystrophy, Animal / drug therapy,  physiopathology*
Phenytoin / pharmacology
Reproduction* / drug effects
Rodent Diseases / drug therapy,  physiopathology*
Sexual Behavior, Animal / drug effects
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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