| Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. | |
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MedLine Citation:
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PMID: 19074743 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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New studies have revealed an essential role for TRPA1, a sensory neuronal TRP ion channel, in airway chemosensation and inflammation. TRPA1 is activated by chlorine, reactive oxygen species, and noxious constituents of smoke and smog, initiating irritation and airway reflex responses. Together with TRPV1, the capsaicin receptor, TRPA1 may contribute to chemical hypersensitivity, chronic cough, and airway inflammation in asthma, COPD, and reactive airway dysfunction syndrome. |
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Authors:
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Bret F Bessac; Sven-Eric Jordt |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Physiology (Bethesda, Md.) Volume: 23 ISSN: 1548-9213 ISO Abbreviation: Physiology (Bethesda) Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-12-16 Completed Date: 2009-02-24 Revised Date: 2010-09-23 |
Medline Journal Info:
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Nlm Unique ID: 101208185 Medline TA: Physiology (Bethesda) Country: United States |
Other Details:
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Languages: eng Pagination: 360-70 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium Channels / genetics, physiology* Cough / physiopathology* Humans Multiple Chemical Sensitivity / genetics, physiopathology* Nerve Tissue Proteins / genetics, physiology* Oxidative Stress / physiology Reflex / physiology TRPV Cation Channels / genetics, physiology* Transient Receptor Potential Channels / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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ES-015056/ES/NIEHS NIH HHS; ES-015674/ES/NIEHS NIH HHS; R01 ES015056-03/ES/NIEHS NIH HHS; U01 ES015674-03/ES/NIEHS NIH HHS; U54 ES017218-010002/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Calcium Channels; 0/Nerve Tissue Proteins; 0/TRPA1 protein, human; 0/TRPV Cation Channels; 0/TRPV1 protein, human; 0/Transient Receptor Potential Channels |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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