Document Detail

Breathing patterns and aerosol delivery: impact of regular human patterns, and sine and square waveforms on rate of delivery.
MedLine Citation:
PMID:  11693844     Owner:  NLM     Status:  MEDLINE    
In vitro tests are commonly employed to assess nebulizer performance. Whether the square or sine waveforms employed during in vitro tests could alter the nebulizer performance compared to that observed when a patient breathes through the nebulizer is debatable. Accordingly, the aim of this in vitro study was to compare the rates of delivery from nebulizers with simulated human breathing patterns to those obtained with matching sine and square waveforms. Regular human breathing patterns with tidal volumes (VT) of approximately 40, approximately 200, approximately 500, and approximately 800 mL were selected. Sine and square waveforms that matched the VT, peak inspiratory flow rate (PIF), breathing frequency (f), and inspiratory duty cycle (t(i)/t(tot)) of the human breathing patterns were created with a breathing simulator. The rate of delivery of nebulized technetium-99m-labeled diethylenetriamine pentaacetic acid (99mTC-DTPA) from two different jet nebulizer brands was determined. The rate of delivery was defined as the amount of the 99mTC-DTPA deposited during 30 sec of nebulization on a filter placed between the nebulizer and the breathing simulator. The rate of delivery of 99mTC-DTPA with the human breathing pattern was similar to that measured with the matching sine or square waveforms for either nebulizer. The configuration of the breath (PIF, VT, f, t(i)/t(tot)) did, however, influence the rate of delivery. In conclusion, the shape of the waveform, in other words, one resulting from a human breathing pattern, or a matching sine or square waveform, did not influence the rate of 99mTC-DTPA delivery from a nebulizer in vitro.
K Nikander; J Denyer; N Smith; P Wollmer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine     Volume:  14     ISSN:  0894-2684     ISO Abbreviation:  J Aerosol Med     Publication Date:  2001  
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8809251     Medline TA:  J Aerosol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  T    
Clinical Science, AstraZeneca R&D, Lund, Sweden.
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MeSH Terms
Aerosols / administration & dosage*
Nebulizers and Vaporizers*
Radiopharmaceuticals / diagnostic use
Technetium Tc 99m Pentetate / diagnostic use
Reg. No./Substance:
0/Aerosols; 0/Radiopharmaceuticals; 65454-61-7/Technetium Tc 99m Pentetate

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