Document Detail

Breathing muscle activity during expiration in patients with chronic airflow obstruction.
MedLine Citation:
PMID:  2292286     Owner:  NLM     Status:  MEDLINE    
During quiet ventilation in 10 patients with severe chronic airflow obstruction (AFO) there were large tidal swings of pleural pressure, 15.8 +/- 5.1 cmH2O, with high negative pressures achieved, 15.2 +/- 5.2 cmH2O. The pattern of pleural pressure mirrored that of tidal expiratory flow with a rapid rise to maximum of pleural pressure and flow at the beginning of expiration, a slow decline of both throughout most of expiration, and just before the onset of inspiration at flow reversal, a sharp fall in pleural pressure and expiratory flow. The shape of expiratory flow and pleural pressure tracings and the pattern of EMG recordings are compatible with loss of post-inspiratory muscle braking of flow. The generally negative pleural pressure and the EMG silence during expiration indicated relaxation of expiratory muscles throughout expiration. Extrapolation of the tidal expiratory flow curve to zero, and calculation of the area under the extrapolated curve showed the volume of dynamic hyperinflation to be a small proportion of the total increase in functional residual capacity above the predicted value in these patients.
M J Morris; R G Madgwick; A J Frew; D J Lane
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The European respiratory journal     Volume:  3     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1991-04-09     Completed Date:  1991-04-09     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  901-9     Citation Subset:  IM    
Osler Chest Unit, Churchill Hospital, Oxford, UK.
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MeSH Terms
Lung Compliance
Lung Diseases, Obstructive / physiopathology*
Middle Aged
Respiration / physiology*
Respiratory Function Tests
Respiratory Mechanics
Respiratory Muscles / physiopathology*
Tidal Volume

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