Document Detail


Breathing during cardiac arrest following exercise: a new function of the respiratory system?
MedLine Citation:
PMID:  22465526     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have found in four sheep that, following a muscular exercise, minute ventilation is maintained for 34-131 s during a cardiac arrest (CA), at a magnitude (from 28.2 and 54.7 l min(-1)) similar to the level of ventilation (and thus proportional to the metabolic rate) preceding the period of asystole. Breathing was maintained despite the lack of pulmonary blood flow and the cessation of the muscle contractions, leading to a dramatic reduction in alveolar FCO(2) (1.9 ± 1%). Secondly, swings in arterial blood pressure (ABP) were observed (pulse pressure of 31 ± 3 Torr) in phase with breathing movements in place of the cardiac activity. This "protective" response, deprived from any role in blood gas homeostasis, as circulation is virtually abolished, is not predictable from the traditional respiratory control feedback systems thought to be involved in exercise. We are presenting the view that this response, dissociated from the pulmonary gas exchanges, is the expression of a rudimentary defense mechanism aimed at limiting the consequences of an acute failure of the cardiac pump by the thoraco-abdominal pump.
Authors:
Philippe Haouzi; Andry Van De Louw; Alice Haouzi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-23
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  181     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-08-30     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  220-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Heart Arrest / physiopathology*
Hemodynamics / physiology
Physical Conditioning, Animal / physiology*
Respiration*
Respiratory System / physiopathology*
Sheep
Ventricular Fibrillation / etiology,  physiopathology
Comments/Corrections
Erratum In:
Respir Physiol Neurobiol. 2014 Jul 1;198():48

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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