Document Detail

Breathing at high altitude.
MedLine Citation:
PMID:  19756384     Owner:  NLM     Status:  MEDLINE    
Acclimatization to long-term hypoxia takes place at high altitude and allows gradual improvement of the ability to tolerate the hypoxic environment. An important component of this process is the hypoxic ventilatory acclimatization (HVA) that develops over several days. HVA reveals profound cellular and neurochemical re-organization occurring both in the peripheral chemoreceptors and in the central nervous system (in brainstem respiratory groups). These changes lead to an enhanced activity of peripheral chemoreceptor and re-inforce the central translation of peripheral inputs to efficient respiratory motor activity under the steady low O(2) pressure. We will review the cellular processes underlying these changes with a particular emphasis on changes of neurotransmitter function and ion channel properties in peripheral chemoreceptors, and present evidence that low O(2) level acts directly on brainstem nuclei to induce cellular changes contributing to maintain a high tonic respiratory drive under chronic hypoxia.
Vincent Joseph; Jean-Marc Pequignot
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Publication Detail:
Type:  Journal Article; Review     Date:  2009-09-10
Journal Detail:
Title:  Cellular and molecular life sciences : CMLS     Volume:  66     ISSN:  1420-9071     ISO Abbreviation:  Cell. Mol. Life Sci.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2010-01-21     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9705402     Medline TA:  Cell Mol Life Sci     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  3565-73     Citation Subset:  IM    
Department of Pediatrics, Laval University, Centre de Recherche (D0-711), Hôpital St-François d'Assise, 10 rue de l'Espinay, Quebec, QC, G1L 3L5, Canada.
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MeSH Terms
Anoxia / physiopathology
Carotid Body / physiopathology
Central Nervous System / physiopathology
Models, Biological
Oxygen Consumption / physiology

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