Document Detail

Breath sulfides and pulmonary function in cystic fibrosis.
MedLine Citation:
PMID:  16247007     Owner:  NLM     Status:  MEDLINE    
We have determined the concentrations of carbonyl sulfide (OCS), dimethylsulfide, and carbon disulfide (CS(2)) in the breath of a group of cystic fibrosis (CF) patients and one of healthy controls. At the detection sensitivity in these experiments, room air always contained measurable quantities of these three gases. For each subject the inhaled room concentrations were subtracted from the time-coincident concentrations in exhaled breath air. The most significant differences between the CF and control cohorts in these breath-minus-room values were found for OCS. The control group demonstrated a net uptake of 250 +/- 20 parts-per-trillion-by-volume (pptv), whereas the CF cohort had a net uptake of 110 +/- 60 pptv (P = 0.00003). Three CF patients exhaled more OCS than they inhaled from the room. The OCS concentrations in the CF cohort were strongly correlated with pulmonary function. The dimethylsulfide concentrations in breath were greatly enhanced over ambient, but no significant difference was observed between the CF and healthy control groups. The net (breath minus room) CS(2) concentrations for individuals ranged between +180 and -100 pptv. They were slightly greater in the CF cohort (+26 +/- 38 pptv) vs. the control group (-17 +/- 15 pptv; P = 0.04). Lung disease in CF is accompanied by the subsistence of chronic bacterial infections. Sulfides are known to be produced by bacteria in various systems and were therefore the special target for this investigation. Our results suggest that breath sulfide content deserves attention as a noninvasive marker of respiratory colonization.
M A Kamboures; D R Blake; D M Cooper; R L Newcomb; M Barker; J K Larson; S Meinardi; E Nussbaum; F S Rowland
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-10-24
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  102     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-11-02     Completed Date:  2005-12-21     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15762-7     Citation Subset:  IM    
Department of Chemistry, University of California, Irvine, CA 92697-2025, USA.
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MeSH Terms
Breath Tests / methods
Carbon Disulfide / analysis
Case-Control Studies
Cystic Fibrosis / diagnosis*,  microbiology
Respiratory Function Tests / methods,  standards
Respiratory System / microbiology
Sulfides / analysis*
Sulfur Oxides / analysis
Grant Support
Reg. No./Substance:
0/Sulfides; 0/Sulfur Oxides; 463-58-1/carbonyl sulfide; 75-15-0/Carbon Disulfide; 75-18-3/dimethyl sulfide

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