| Breath pentane and plasma lipid peroxides in ischemic heart disease. | |
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MedLine Citation:
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PMID: 8529928 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study examined the relationship between breath pentane and plasma lipid peroxide levels sampled simultaneously in patients with stable angina (n = 17), unstable angina (n = 23), and controls (n = 10). Plasma lipid peroxides were measured in venous blood as the adduct formed between thiobarbituric acid and malondialdehyde (MDA) using high performance liquid chromatography. Pentane was measured in end-expiratory air using gas chromatography. MDA concentrations in stable (1.81 +/- 0.84 mumol/l) and unstable (1.5 +/- 1.23 mumol/l) angina were not different. However, both groups had significantly (p < 0.005) elevated MDA levels compared to controls (0.41 +/- 0.26 mumol/l). Breath pentane was 0.20 +/- 0.12 nmol/l in controls and not different from stable angina (0.26 +/- 0.20 nmol/l) or unstable angina (0.15 +/- 0.07 nmol/l). When the data from all three groups were combined, there was no correlation between pentane and MDA (rho = -0.09, p = 0.54). In five of the unstable angina patients treated with balloon angioplasty, MDA in pulmonary arterial blood rose by 69 +/- 15% (p < 0.01), and breath pentane rose by 73 +/- 20% (p < 0.01) immediately after balloon deflation. One minute after balloon deflation MDA and pentane had returned to preinflation levels. The results suggest that basal levels of pentane are less useful than MDA as an index of lipid peroxidation in patients with coronary artery disease. However, breath pentane appears to be a sensitive index of reperfusion-induced lipid peroxidation. |
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Authors:
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S Mendis; P A Sobotka; F L Leja; D E Euler |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Free radical biology & medicine Volume: 19 ISSN: 0891-5849 ISO Abbreviation: Free Radic. Biol. Med. Publication Date: 1995 Nov |
Date Detail:
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Created Date: 1996-02-01 Completed Date: 1996-02-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8709159 Medline TA: Free Radic Biol Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 679-84 Citation Subset: IM |
Affiliation:
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Department of Medicine, Loyola University Medical Center, Maywood, IL 60153, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angina Pectoris / blood, metabolism* Angina, Unstable / blood, metabolism* Biological Markers / analysis, blood Butadienes / analysis Cholesterol / blood Female Hemiterpenes* Humans Lipid Peroxides / blood* Male Malondialdehyde / blood Middle Aged Myocardial Ischemia / blood, metabolism* Pentanes / analysis* Reference Values Respiration* Smoking Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Butadienes; 0/Hemiterpenes; 0/Lipid Peroxides; 0/Pentanes; 0/Triglycerides; 109-66-0/pentane; 542-78-9/Malondialdehyde; 57-88-5/Cholesterol; 78-79-5/isoprene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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