Document Detail

Breath malodor in an asthmatic patient caused by side-effects of medication: a case report and review of the literature.
MedLine Citation:
PMID:  14628896     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this report is to document the presence of dimethyl sulfide in mouth air as the predominant volatile sulfur compound (VSC) in an asthmatic patient who was regularly taking suplatast tosilate. STUDY DESIGN: The patient was a 33-year-old woman who complained of bad breath. She had been diagnosed as having asthma and was receiving periodical medical examinations once a month. VSC in her mouth air were measured with a gas chromatograph. Oral physiotherapy was also carried out to remove any oral malodor of which the source was intraoral. RESULTS: With the improvement in oral hygiene and periodontal conditions, the level of VSC was reduced but dimethyl sulfide still remained as the predominant VSC. CONCLUSIONS: Dimethyl sulfide metabolized from suplatast tosilate may be a potential cause of halitosis.
T Murata; Y Fujiyama; T Yamaga; H Miyazaki
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Oral diseases     Volume:  9     ISSN:  1354-523X     ISO Abbreviation:  Oral Dis     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2003-12-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9508565     Medline TA:  Oral Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  273-6     Citation Subset:  D    
Division of Preventive Dentistry, Department of Oral Health Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
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MeSH Terms
Anti-Asthmatic Agents / adverse effects*
Arylsulfonates / adverse effects
Asthma / drug therapy
Chromatography, Gas
Halitosis / chemically induced*,  metabolism
Sulfides / analysis
Sulfonium Compounds / adverse effects
Reg. No./Substance:
0/Anti-Asthmatic Agents; 0/Arylsulfonates; 0/Sulfides; 0/Sulfonium Compounds; 75-18-3/dimethyl sulfide; 94055-76-2/suplatast tosilate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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