Document Detail

Breastfeeding during infancy and the risk of cardiovascular disease in adulthood.
MedLine Citation:
PMID:  15308954     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Numerous studies have reported associations between the type of feeding during infancy and subsequent cardiovascular risk factors. Only 2 studies have evaluated the relation between having been breastfed and the risk of adult cardiovascular events. METHODS: We examined this association among 87,252 female participants of the longitudinal Nurses' Health Study. Participants (all born between 1921 and 1946) reported in 1992 whether and for how long they were breastfed. During 8 years of follow up, there were 1099 cases of coronary heart disease and 940 strokes among women who knew whether they had been breastfed. We used proportional hazards models to estimate hazard ratios for cardiovascular events, adjusting for changing adult risk factors. RESULTS: Compared with women who were never breastfed, women who were breastfed had hazard ratios of 0.92 (95% confidence interval = 0.80-1.05) for coronary heart disease and 0.91 (0.79-1.06) for stroke, after adjustment for age, birthweight, and smoking. When body mass index was also included in the model, the results were similar. Looking within subgroups of stroke, hazard ratios were 0.86 (0.70-1.07) for ischemic stroke and 1.01 (0.70-1.46) for hemorrhagic stroke. Comparing women who were breastfed at least 9 months with those who were not breastfed, the hazard ratios were 0.84 (0.69-1.03) for coronary heart disease and 1.00 (0.81-1.23) for stroke. Breastfeeding history was not associated with high blood pressure in adulthood. CONCLUSIONS: These data suggest, but cannot establish, that breastfeeding in infancy may be associated with a small reduction in risk of ischemic cardiovascular disease in adulthood.
Janet W Rich-Edwards; Meir J Stampfer; JoAnn E Manson; Bernard Rosner; Frank B Hu; Karin B Michels; Walter C Willett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  15     ISSN:  1044-3983     ISO Abbreviation:  Epidemiology     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-13     Completed Date:  2005-01-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  550-6     Citation Subset:  IM    
Department of Ambulatory Care and Prevention, Harvard Medical School and Harvard Pilgrim Health Care, Boston, Massachusetts 02215, USA.
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MeSH Terms
Body Mass Index
Breast Feeding*
Cardiovascular Diseases / epidemiology*
Cohort Studies
Coronary Disease / epidemiology
Hypertension / epidemiology
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Middle Aged
Prospective Studies
Risk Factors
Stroke / epidemiology
United States / epidemiology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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