Document Detail

Breastfeeding of newborns by mothers carrying hepatitis B virus: a meta-analysis and systematic review.
MedLine Citation:
PMID:  21536948     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To perform a systematic review of prospective studies to confirm the role of breastfeeding in mother-to-child transmission (MTCT) of hepatitis B virus (HBV).
DATA SOURCES: A database was constructed from MEDLINE, EMBASE, Cochrane Library, National Science Digital Library, and China Biological Medicine Database and through contact with experts in this field from January 1, 1990, to August 31, 2010.
STUDY SELECTION: All studies were peer reviewed and met the preset inclusion standards.
MAIN EXPOSURE: Breastfeeding.
MAIN OUTCOME MEASURES: Data regarding HBV intrauterine infection, MTCT, maternal blood and breast milk infectiousness, infant immunoprophylaxis methods and response, and adverse events. The Mantel-Haenszel fixed-effects model was used for all analyses using odds ratios and 95% confidence intervals.
RESULTS: Ten qualified studies were included. All were clinical controlled trials, involving 751 infants in the breastfeeding group and 873 infants in the nonbreastfeeding group. As indicated by infant peripheral blood hepatitis B surface antigen or HBV DNA positivity at age 6 to 12 months, the odds ratio of MTCT of HBV in the breastfeeding group compared with that in the nonbreastfeeding group was 0.86 (95% confidence interval, 0.51-1.45) (from 8 clinical controlled trials, P = .56; I(2) = 0%, P = .99). As indicated by infant peripheral blood hepatitis B surface antibody positivity at age 6 to 12 months, the odds ratio of development of hepatitis B surface antibodies in the breastfeeding group compared with that in the nonbreastfeeding group was 0.98 (95% confidence interval, 0.69-1.40) (from 8 clinical controlled trials, P = .93; I(2) = 0%, P = .99). No adverse events or complications during breastfeeding were observed.
CONCLUSION: Breastfeeding after proper immunoprophylaxis did not contribute to MTCT transmission of HBV.
Zhongjie Shi; Yuebo Yang; Hao Wang; Lin Ma; Ann Schreiber; Xiaomao Li; Wenjing Sun; Xuan Zhao; Xu Yang; Liran Zhang; Wenli Lu; Jin Teng; Yufang An
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2011-05-02
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  165     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-06     Completed Date:  2011-10-31     Revised Date:  2012-09-25    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  837-46     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynecology, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
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MeSH Terms
Breast Feeding*
Hepatitis B / blood,  prevention & control,  transmission*
Hepatitis B Antibodies / blood
Hepatitis B Surface Antigens / blood
Infant, Newborn
Infectious Disease Transmission, Vertical*
Milk, Human / virology*
Pregnancy Complications, Infectious / blood,  prevention & control,  virology
Reg. No./Substance:
0/Hepatitis B Antibodies; 0/Hepatitis B Surface Antigens
Comment In:
Evid Based Med. 2012 Aug;17(4):125-6   [PMID:  22187494 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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