| Breast- v. formula-feeding: impacts on the digestive tract and immediate and long-term health effects. | |
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MedLine Citation:
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PMID: 20450531 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The health benefits of breast-feeding have been recognised for a long time. In particular, breast-feeding is associated with lower incidence of necrotising enterocolitis and diarrhoea during the early period of life and with lower incidence of inflammatory bowel diseases, type 2 diabetes and obesity later in life. The higher nutritional and protective degree of human milk is related to its nutritional composition that changes over the lactation period and to the biological activities of specific components while lower growth rate of breast-fed infants may be attributed to their self-regulation of milk intake at a lower level than formula-fed infants. Many results now suggest that the developmental changes in intestinal and pancreatic function that occur postnatally are modulated by the diet. Indeed, formula-feeding induces intestinal hypertrophy and accelerates maturation of hydrolysis capacities; it increases intestinal permeability and bacterial translocation, but does not induce evident differences in microbiota composition. Whether these changes would be beneficial for enhancing absorptive capacities and for educating the gut-associated immune system remains to be further studied. Moreover, it is evident that formula-feeding increases basal blood glucose and decreases plasma ketone body concentrations, while discrepancies on postprandial glycaemia, insulin and incretin responses in both human studies and experimental studies are inconclusive. Manipulating the composition of formula, by reducing protein content, adding prebiotics, growth factors or secretory IgA can modulate intestinal and pancreatic function development, and thereby may reduce the differential responses between breast-fed and formula-fed neonates. However, the developmental responses of the digestive tract to different feeding strategies must be elucidated in terms of sensitivity to developing diseases, taking into account the major role of the intestinal microbiota. |
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Authors:
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Isabelle Le Huërou-Luron; Sophie Blat; Gaëlle Boudry |
Publication Detail:
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Type: Comparative Study; Journal Article; Review Date: 2010-05-10 |
Journal Detail:
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Title: Nutrition research reviews Volume: 23 ISSN: 1475-2700 ISO Abbreviation: Nutr Res Rev Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-07-01 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9113797 Medline TA: Nutr Res Rev Country: England |
Other Details:
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Languages: eng Pagination: 23-36 Citation Subset: IM |
Affiliation:
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INRA, UMR 1079, SENAH, F-35590 Saint-Gilles, France. Isabelle.Luron@rennes.inra.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / analysis Breast Feeding* Diabetes Mellitus, Type 2 / prevention & control Diarrhea / prevention & control Digestive System* / growth & development Enterocolitis, Necrotizing / prevention & control Female Health Promotion Health Status* Humans Infant Infant Formula* / chemistry Infant Nutritional Physiological Phenomena Infant, Newborn Inflammatory Bowel Diseases / prevention & control Intestines / microbiology, physiology Ketone Bodies / blood Milk, Human / chemistry Nutritive Value Obesity / prevention & control Pancreas / physiology Weight Gain |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Ketone Bodies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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