Document Detail


Breast-gut connection: origin of chenodeoxycholic acid in breast cyst fluid.
MedLine Citation:
PMID:  7906811     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The notion that a breast-gut connection might modulate the microenvironment of breast tissue was supported by the finding that breast cyst fluid contains bile acids that are characteristically found in the intestines. To establish that the gut, rather than circulating steroid precursors, is the source of bile acids in breast cyst fluid, we gave two patients deuterium-labelled chenodeoxycholic acid (three 200 mg doses by mouth), starting 9 days before aspiration of breast cysts. The chenodeoxycholic acid concentration of seven samples of aspirated cyst fluid ranged from 42 to 94 mumol/L. The corresponding serum concentrations of chenodeoxycholic acid on the same day were 0.8 and 2.9 mumol/L, of which the labelled compound comprised 13.0% (0.38 mumol/L) and 28.2% (0.23 mumol/L). The deuterated chenodeoxycholic acid concentrations in cyst fluid were 0.79 and 1.26 mumol/L in two samples from patient 1 and 3.22 mumol/L in patient 2; these values are equivalent to 11-17% of the serum concentrations [corrected]. This study shows that intestinal bile acids rapidly gain access to cyst fluid. Further studies should investigate the mechanisms that govern the exchange processes and the maintenance of the high cyst fluid to plasma concentration gradients, and the biological half-lives of individual constituents.
Authors:
N B Javitt; K Budai; D G Miller; A C Cahan; U Raju; M Levitz
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Lancet     Volume:  343     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-03-28     Completed Date:  1994-03-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  633-5     Citation Subset:  AIM; IM    
Affiliation:
Division of Hepatic Diseases, New York University Medical Center, NY 10016.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chenodeoxycholic Acid / analysis*,  blood,  physiology
Cholic Acids / analysis,  blood
Deoxycholic Acid / analysis,  blood
Deuterium / diagnostic use
Exudates and Transudates / chemistry
Female
Fibrocystic Breast Disease / chemistry*,  physiopathology
Humans
Middle Aged
Grant Support
ID/Acronym/Agency:
CA02071/CA/NCI NIH HHS; DK32995/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Cholic Acids; 474-25-9/Chenodeoxycholic Acid; 7782-39-0/Deuterium; 83-44-3/Deoxycholic Acid
Comments/Corrections
Erratum In:
Lancet 1994 Apr 16;343(8903):986

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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