| Breast-feeding and risk of epithelial ovarian cancer. | |
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MedLine Citation:
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PMID: 22527170 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Evidence suggests that breast-feeding may decrease the risk of epithelial ovarian cancer but it is not clear whether there is a relationship with duration of breast-feeding, patterns of breast-feeding, or particular histological subtypes of ovarian cancer. We sought to investigate these issues in detail. METHODS: Data from participants in a population-based study of ovarian cancer in western Washington State, USA (2002-2007) who had had at least one birth (881 cases and 1,345 controls) were used to assess relations between patterns of breast-feeding and ovarian cancer. Logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CI). RESULTS: Women who ever breast-fed had a 22 % reduction in risk of ovarian cancer compared with those who never breast-fed (OR = 0.78, 95% CI 0.64-0.96) and risk reduction appeared greater with longer durations of feeding per child breast-fed (OR = 0.56, 95% CI 0.32-0.98 for 18 months average duration breast-feeding versus none). Introduction of supplementary feeds did not substantially alter these effects. The overall risk reduction appeared greatest for the endometrioid and clear cell subtypes (OR per month of average breast-feeding per child breast-fed = 0.944, 95% CI 0.903-0.987). CONCLUSIONS: Among women who have had the opportunity to breast-feed, ever breast-feeding and increasing durations of episodes of breast-feeding for each breast-fed child are associated with a decrease in the risk of ovarian cancer independent of numbers of births, which may be strongest for the endometrioid subtype. |
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Authors:
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S J Jordan; K L Cushing-Haugen; K G Wicklund; J A Doherty; M A Rossing |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-04-24 |
Journal Detail:
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Title: Cancer causes & control : CCC Volume: 23 ISSN: 1573-7225 ISO Abbreviation: Cancer Causes Control Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-11 Completed Date: 2012-11-08 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9100846 Medline TA: Cancer Causes Control Country: Netherlands |
Other Details:
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Languages: eng Pagination: 919-27 Citation Subset: IM |
Affiliation:
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School of Population Health, The University of Queensland, Herston, Australia. susan.jordan@qimr.edu.au |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Breast Feeding / statistics & numerical data* Case-Control Studies Confidence Intervals Female Humans Logistic Models Middle Aged Neoplasms, Glandular and Epithelial / epidemiology*, prevention & control Odds Ratio Ovarian Neoplasms / epidemiology*, prevention & control Risk Factors Washington / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA087538/CA/NCI NIH HHS; R01 CA112523/CA/NCI NIH HHS; R01 CA112523/CA/NCI NIH HHS; R01 CA87538/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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