Document Detail


Breast-feeding during treatment with cyclosporine.
MedLine Citation:
PMID:  9458024     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Mothers treated with cyclosporine (CsA) have previously not been allowed to breast-feed due to the reported accumulation of the drug in breast milk. The purpose of this study was to evaluate the consequences of allowing breast-feeding. METHODS: Seven infants were breast-fed by mothers who had undergone kidney transplantation alone (n=5) or simultaneous kidney and pancreas transplants (n=2). In addition to CsA, all mothers received prednisolone at 5-7.5 mg/day and six mothers received azathioprine at 50-100 mg. CsA concentration was measured in the whole blood of mothers and babies and in breast milk. Serum creatinine was measured in babies 1 week after birth and after 4-12 months of breast-feeding. RESULTS: Blood CsA levels ranged from 55 to 130 ng/ml in mothers (12-hr trough), 50 to 227 ng/ml in breast milk (mean for each woman), and was below the detection limit of 30 ng/ml in all infants. Breast milk concentration ranged from 87 to 440 ng/ml in 16 samples obtained at various time points from one mother. Infants' serum creatinine ranged from 25 to 54 micromol/L at 1 week after birth and 23-52 micromol/L after breast-feeding. All babies thrived. CONCLUSIONS: Breast-fed infants of mothers treated with CsA received less than 300 microg per day of CsA and absorbed undetectable amounts. There were no demonstrable nephrotoxic effects or other side effects. Thus, women with kidney transplants could be allowed to breast-feed.
Authors:
G Nyberg; U Haljamäe; C Frisenette-Fich; M Wennergren; I Kjellmer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  65     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-02-11     Completed Date:  1998-02-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  253-5     Citation Subset:  IM    
Affiliation:
Transplant Unit, Sahlgrenska University Hospital, Göteborg, Sweden.
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MeSH Terms
Descriptor/Qualifier:
Adult
Azathioprine / therapeutic use
Breast Feeding*
Creatinine / blood
Cyclosporine / analysis,  blood,  pharmacokinetics*,  therapeutic use
Female
Glucocorticoids / therapeutic use
Humans
Immunosuppression*
Immunosuppressive Agents / analysis,  blood,  pharmacokinetics*,  therapeutic use
Infant
Infant, Newborn
Kidney Transplantation*
Milk, Human / chemistry
Pancreas Transplantation
Prednisolone / therapeutic use
Chemical
Reg. No./Substance:
0/Glucocorticoids; 0/Immunosuppressive Agents; 446-86-6/Azathioprine; 50-24-8/Prednisolone; 59865-13-3/Cyclosporine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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