Document Detail

Breast-feeding by a cyclosporine-treated mother.
MedLine Citation:
PMID:  11336764     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cyclosporine is known to be excreted in breast milk, but levels in infants are not known. Post-transplant breast-feeding has been contraindicated in mothers treated with calcineurin inhibitors such as cyclosporine. CASE: A 35-year-old woman exclusively breast-fed her infant during the first 10.5 months of life while she was being treated with cyclosporine. Cyclosporine measurements in infant and maternal blood and breast milk revealed a mean breast milk/maternal blood level ratio of 84%, but undetectable levels in the infant. The infant grew and developed normally. CONCLUSION: The infant of a cyclosporine-treated mother was breast-fed exclusively during the first 10.5 months of life and did not absorb a detectable amount of the drug. Fetal growth and development were normal.
K D Munoz-Flores-Thiagarajan; T Easterling; C Davis; E F Bond
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  97     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-04     Completed Date:  2001-05-24     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  816-8     Citation Subset:  AIM; IM    
Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Box 357266, Seattle, WA 98195, USA.
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MeSH Terms
Breast Feeding*
Cyclosporine / metabolism*,  therapeutic use
Diabetes Mellitus, Type 1
Immunosuppressive Agents / metabolism*,  therapeutic use
Infant, Newborn
Kidney Failure, Chronic
Kidney Transplantation*
Milk, Human / metabolism*
Pancreas Transplantation*
Postpartum Period
Pregnancy Complications / therapy*
Grant Support
Reg. No./Substance:
0/Immunosuppressive Agents; 59865-13-3/Cyclosporine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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