| Breast disease: clinical application of US elastography for diagnosis. | |
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MedLine Citation:
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PMID: 16484352 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the diagnostic performance of real-time freehand elastography by using the extended combined autocorrelation method (CAM) to differentiate benign from malignant breast lesions, with pathologic diagnosis as the reference standard. MATERIALS AND METHODS: This study was approved by the University of Tsukuba Human Subjects Institutional Review Board; all patients gave informed consent. Conventional ultrasonography (US) and real-time US elastography with CAM were performed in 111 women (mean age, 49.4 years; age range, 27-91 years) who had breast lesions (59 benign, 52 malignant). Elasticity images were assigned an elasticity score according to the degree and distribution of strain induced by light compression. The area under the curve and cutoff point, both of which were obtained by using a receiver operating characteristic curve analysis, were used to assess diagnostic performance. Mean scores were examined by using a Student t test. Sensitivity, specificity, and accuracy were compared by using the standard proportion difference test or the Delta-equivalent test. RESULTS: For elasticity score, the mean +/- standard deviation was 4.2 +/- 0.9 for malignant lesions and 2.1 +/- 1.0 for benign lesions (P < .001). When a cutoff point of between 3 and 4 was used, elastography had 86.5% sensitivity, 89.8% specificity, and 88.3% accuracy. When a best cutoff point of between 4 and 5 was used, conventional US had 71.2% sensitivity, 96.6% specificity, and 84.7% accuracy. Elastography had higher sensitivity than conventional US (P < .05). By using equivalence bands for noninferiority or equivalence, it was shown that the specificity of elastography was not inferior to that of conventional US and that the accuracy of elastography was equivalent to that of conventional US. CONCLUSION: For assessing breast lesions, US elastography with the proposed imaging classification, which was simple compared with that of the Breast Imaging Recording and Data System classification, had almost the same diagnostic performance as conventional US. |
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Authors:
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Ako Itoh; Ei Ueno; Eriko Tohno; Hiroshi Kamma; Hideto Takahashi; Tsuyoshi Shiina; Makoto Yamakawa; Takeshi Matsumura |
Publication Detail:
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Type: Journal Article Date: 2006-02-16 |
Journal Detail:
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Title: Radiology Volume: 239 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-27 Completed Date: 2006-06-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 341-50 Citation Subset: AIM; IM |
Copyright Information:
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(c) RSNA, 2006. |
Affiliation:
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Department of Breast and Endocrine Surgery, Tsukuba University Hospital, University of Tsukuba, Tsukuba, Japan. ako.itou@ibabyo.hitachi.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Breast Diseases / pathology, ultrasonography* Breast Neoplasms / pathology, ultrasonography* Diagnosis, Differential Elasticity Humans Middle Aged Reproducibility of Results Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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