| Breast development in the first 2 years of life: an association with soy-based infant formulas. | |
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MedLine Citation:
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PMID: 18223379 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate the estrogenic effect of soy-based formulas in female infants. These formulas contain significant amounts of phytoestrogens, compounds with structural similarity to estradiol. PATIENTS AND METHODS: A cross-sectional study consisting of 694 female infants ages 3 to 24 months that consecutively attended 10 general pediatric clinics, none of them having been referred for breast development. The presence of breast buds served as a marker for the endocrine effect of soy-derived phytoestrogens. RESULTS: Of the participants, 92 had consumed soy formulas for more than 3 months. Breast tissue was more prevalent in the second year of life in infants fed soy-based formula vs those that were breast-fed and those fed dairy-based formula (22.0% vs 10.3%; P = 0.02) with an odds ratio of 2.45 (95% confidence interval 1.11-5.39). No differences in breast bud prevalence were observed during the first year of life. Unlike infants on dairy-based formulas and breast-feeding, infants fed a soy-based formula did not demonstrate a decline in the prevalence of breast during the second year of life. CONCLUSIONS: We suggest that phytoestrogens impose a preserving effect on breast tissue that is evolved in early infancy, leading eventually to a slower waning of infantile breast tissue. |
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Authors:
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Amnon Zung; Tamar Glaser; Zohar Kerem; Zvi Zadik |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pediatric gastroenterology and nutrition Volume: 46 ISSN: 1536-4801 ISO Abbreviation: J. Pediatr. Gastroenterol. Nutr. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-28 Completed Date: 2008-03-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8211545 Medline TA: J Pediatr Gastroenterol Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 191-5 Citation Subset: IM |
Affiliation:
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Pediatric Endocrinology Unit, Kaplan Medical Center, Hadassah Medical School, Jerusalem, Israel. amzung2@bezeqint.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Breast
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drug effects*,
growth & development* Child, Preschool Cross-Sectional Studies Female Humans Infant Infant Formula* Infant Nutritional Physiological Phenomena Phytoestrogens / administration & dosage, pharmacology* Risk Factors Soy Milk / chemistry* Statistics, Nonparametric Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Phytoestrogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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