Document Detail

Breast conservation is a safe method in patients with small cancer of the breast. Long-term results of three randomised trials on 1,973 patients.
MedLine Citation:
PMID:  7488404     Owner:  NLM     Status:  MEDLINE    
Breast conservation has become well-established in the treatment of early mammary carcinoma. However, a standardised treatment modality has not emerged. We have analysed the data from 1,973 patients treated in three consecutive randomised trials by four different radiosurgical procedures: Halsted mastectomy, quadrantectomy plus radiotherapy, lumpectomy plus radiotherapy, and quadrantectomy without radiotherapy, to compare the outcomes of these procedures in terms of local recurrence rate and overall survival. Eligibility criteria were similar in the three trials, and comparability between the four subgroups was excellent. Median follow-up for all patients was 82 months. The annual rates of local recurrence varied markedly according to the treatment. Patients treated with Halsted mastectomy and quadrantectomy plus radiotherapy had low annual rates of local recurrence (0.20 and 0.46, respectively) while both lumpectomy plus radiotherapy and quadrantectomy without radiotherapy had significantly higher rates (2.45 and 3.28, respectively). Patients under 45 years of age had a much higher incidence of local recurrences, while in women over 55 years local recurrences were much less frequent. Overall survival curves were identical in the four groups of patients, so that the three breast conserving radiosurgical procedures had the same survival rates as Halsted mastectomy. However, local recurrence rates were markedly influenced by the treatment method, patient age and specific histological features.
U Veronesi; B Salvadori; A Luini; M Greco; R Saccozzi; M del Vecchio; L Mariani; S Zurrida; F Rilke
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Publication Detail:
Type:  Clinical Trial; Journal Article; Meta-Analysis; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of cancer (Oxford, England : 1990)     Volume:  31A     ISSN:  0959-8049     ISO Abbreviation:  Eur. J. Cancer     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9005373     Medline TA:  Eur J Cancer     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1574-9     Citation Subset:  IM    
Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy.
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MeSH Terms
Breast Neoplasms / epidemiology,  surgery*
Mastectomy, Radical*
Mastectomy, Segmental / methods*
Middle Aged
Neoplasm Recurrence, Local / epidemiology
Radiotherapy, Adjuvant
Randomized Controlled Trials as Topic
Survival Rate
Comment In:
Eur J Cancer. 1995 Sep;31A(10):1567-9   [PMID:  7488402 ]

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