| Breast cancer risk factors in African-American women: the Howard University Tumor Registry experience. | |
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MedLine Citation:
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PMID: 8126744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This retrospective case-control study examines risk factors for breast cancer in African-American women, who recently have shown an increase in the incidence of this malignancy, especially in younger women. Our study involves 503 cases from the Howard University Hospital and 539 controls from the same hospital, seen from 1978 to 1987. Using information culled from medical charts, an analysis of various factors for their effect on breast cancer risk was made. The source of data necessarily meant that some known risk factors were missing. Increases in risk were found for known risk factors such as decreased age at menarche and a family history of breast cancer. No change in risk was observed with single marital status, nulliparity, premenopausal status, or lactation. An increased odds ratio was found for induced abortions, which was significant in women diagnosed after 50 years of age. Spontaneous abortions had a small but significant protective effect in the same subgroup of women. Birth control pill usage conferred a significantly increased risk. It is of note that abortions and oral contraceptive usage, not yet studied in African Americans, have been suggested as possibly contributing to the recent increase in breast cancer in young African-American women. |
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Authors:
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A E Laing; F M Demenais; R Williams; G Kissling; V W Chen; G E Bonney |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of the National Medical Association Volume: 85 ISSN: 0027-9684 ISO Abbreviation: J Natl Med Assoc Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-04-14 Completed Date: 1994-04-14 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503090 Medline TA: J Natl Med Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 931-9 Citation Subset: IM |
Affiliation:
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Division of Biostatistics, Howard University Cancer Ctr, Washington, DC 20060. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group* Age Factors Aged Breast Neoplasms / epidemiology* Case-Control Studies District of Columbia / epidemiology Female Humans Menarche Middle Aged Registries Retrospective Studies Risk Factors Urban Population |
| Comments/Corrections | |
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