Document Detail


Breast cancer risk factors in African-American women: the Howard University Tumor Registry experience.
MedLine Citation:
PMID:  8126744     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This retrospective case-control study examines risk factors for breast cancer in African-American women, who recently have shown an increase in the incidence of this malignancy, especially in younger women. Our study involves 503 cases from the Howard University Hospital and 539 controls from the same hospital, seen from 1978 to 1987. Using information culled from medical charts, an analysis of various factors for their effect on breast cancer risk was made. The source of data necessarily meant that some known risk factors were missing. Increases in risk were found for known risk factors such as decreased age at menarche and a family history of breast cancer. No change in risk was observed with single marital status, nulliparity, premenopausal status, or lactation. An increased odds ratio was found for induced abortions, which was significant in women diagnosed after 50 years of age. Spontaneous abortions had a small but significant protective effect in the same subgroup of women. Birth control pill usage conferred a significantly increased risk. It is of note that abortions and oral contraceptive usage, not yet studied in African Americans, have been suggested as possibly contributing to the recent increase in breast cancer in young African-American women.
Authors:
A E Laing; F M Demenais; R Williams; G Kissling; V W Chen; G E Bonney
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the National Medical Association     Volume:  85     ISSN:  0027-9684     ISO Abbreviation:  J Natl Med Assoc     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503090     Medline TA:  J Natl Med Assoc     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  931-9     Citation Subset:  IM    
Affiliation:
Division of Biostatistics, Howard University Cancer Ctr, Washington, DC 20060.
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MeSH Terms
Descriptor/Qualifier:
Adult
African Continental Ancestry Group*
Age Factors
Aged
Breast Neoplasms / epidemiology*
Case-Control Studies
District of Columbia / epidemiology
Female
Humans
Menarche
Middle Aged
Registries
Retrospective Studies
Risk Factors
Urban Population
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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