| Breast cancer risk associated with abnormal cytology in nipple aspirates of breast fluid and prior history of breast biopsy. | |
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MedLine Citation:
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PMID: 8484374 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The authors previously reported an increased risk of breast cancer in women from the San Francisco Bay Area first enrolled between 1973 and 1980 with proliferative cytologic findings (hyperplasia, moderate hyperplasia, and atypia) compared with women with normal cytologic findings in breast fluids obtained by nipple aspiration and with women from whom breast fluid could not be obtained. To look for factors which might modify the risks associated with cytology, the authors examined several standard breast cancer risk factors: parity, age at first pregnancy, age at menarche, family history of breast cancer, and prior history of breast biopsy. Among women aged 30 years or over, only prior biopsy modified the effect of proliferative cytologic findings on the risk of breast cancer (p < 0.10). For those women with no prior biopsy, breast cancer incidence was 5% (47 of 985) among women with normal cytology and 5% (13 of 277) among women with proliferative findings, whereas among those women with normal cytology and 18% (11 of 62) among women with proliferative cytology. Age-adjusted as well as multivariate-adjusted relative risks indicated that the increased risk of breast cancer associated with proliferative cytologic findings was largely confined to women who had a prior history of breast biopsy. |
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Authors:
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M Wrensch; N L Petrakis; E B King; M M Lee; R Miike |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of epidemiology Volume: 137 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-06-01 Completed Date: 1993-06-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 829-33 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Biostatistics, School of Medicine, University of California, San Francisco 94143-0560. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Biopsy Body Fluids / cytology* Breast / pathology*, secretion Breast Neoplasms / epidemiology, etiology*, pathology Cohort Studies Female Humans Incidence Middle Aged Multivariate Analysis Risk Factors |
| Grant Support | |
ID/Acronym/Agency:
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P01 CA 13556-18/CA/NCI NIH HHS; R01 CA 47288-01/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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