| Breast cancer relative survival after the first recurrence and related prognostic factors | |
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MedLine Citation:
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PMID: 19632693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Information regarding the incidence and prognosis of women who have suffered a recurrence of breast cancer is very variable. The aim of the present study was to determine the incidence of locoregional (LR) and distant recurrence and the survival and its determining factors after first recurrence. PATIENTS AND METHODS: We included all women resident in Guipuzkoa who were diagnosed with invasive, non-disseminated breast cancer during 1995 and 1996 identified via Guipuzkoa's Cancer Registry. Recurrences that occurred up to December 2004 were determined retrospectively and compared with the National Death Registry of 2007 to determine the mortality. Relative survival was calculated by the Hakulinen method. RESULTS: Five hundred and sixty one women with tumours in stages I-III were included, 90% of whom were treated with conservative surgery+radiation therapy, or mastectomy. The median follow-up for recurrence was eight years, with 5,7% of these recurrences being LR and 23% distant metastases. The median follow-up after recurrence was 6,1 years for live patients and 1,04 years for dead ones. The three-year survival was 54% (95% CI: 0,31-0,78) after LR recurrence and 18% (95% CI: 0,09-0,28) after distant recurrence. Multivariate analysis showed that the factors that remained as independent predictors of survival after LR recurrence were time to recurrence, age and degree of differentiation of the initial tumour. Age, time to recurrence and nodal involvement were associated with survival after distant recurrence. CONCLUSIONS: Women younger than 54 at initial diagnosis with short disease-free periods and poorly differentiated tumours with nodal involvement have worse prognosis, which should be taken into account when deciding the therapeutic strategy to be followed upon recurrence. |
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Authors:
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Cristina Sarasqueta; Pablo Mart??nez-Camblor; Arantza Mendiola; I??aki Mart??nez-Pueyo; Maria Jes??s Michelena; Mikel Basterretxea; Javier Recio; Isabel Alvarez; Nerea Larra??aga |
Publication Detail:
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Type: English Abstract; Journal Article Date: 2009-07-25 |
Journal Detail:
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Title: Medicina cl??nica Volume: 133 ISSN: 0025-7753 ISO Abbreviation: Med Clin (Barc) Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-13 Completed Date: 2010-01-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376377 Medline TA: Med Clin (Barc) Country: Spain |
Other Details:
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Languages: spa Pagination: 489-95 Citation Subset: IM |
Affiliation:
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Hospital Donostia, Donostia-San Sebasti??n, Espa??a. cristina.sarasquetaeizaguirre@osakidetza.net |
Vernacular Title:
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Supervivencia relativa en c??ncer de mama despu??s de la primera recidiva y factores pron??stico asociados. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Breast Neoplasms / mortality* Female Humans Incidence Middle Aged Neoplasm Metastasis Neoplasm Recurrence, Local / epidemiology, mortality* Prognosis Survival Rate Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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